Abstract | BACKGROUND:
Iron is necessary for life, but excess iron can be toxic to tissues. Iron is thought to damage tissues primarily by generating oxygen free radicals through the Fenton reaction. METHODS: We present an overview of the evidence supporting iron's potential contribution to a broad range of eye disease using an anatomical approach. RESULTS: GENERAL SIGNIFICANCE:
Iron homeostasis is important for ocular health.
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Authors | Allison Loh, Majda Hadziahmetovic, Joshua L Dunaief |
Journal | Biochimica et biophysica acta
(Biochim Biophys Acta)
Vol. 1790
Issue 7
Pg. 637-49
(Jul 2009)
ISSN: 0006-3002 [Print] Netherlands |
PMID | 19059309
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Antioxidants
- Iron Chelating Agents
- Reactive Oxygen Species
- Iron
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Topics |
- Antioxidants
(therapeutic use)
- Cataract
(etiology)
- Corneal Diseases
(chemically induced, etiology)
- Eye Diseases
(physiopathology, prevention & control)
- Homeostasis
- Humans
- Iron
(metabolism)
- Iron Chelating Agents
(therapeutic use)
- Iron Overload
(physiopathology)
- Keratoconus
(pathology)
- Macular Degeneration
(physiopathology)
- Optic Nerve Diseases
(physiopathology)
- Optic Nerve Injuries
(physiopathology)
- Pterygium
(pathology)
- Reactive Oxygen Species
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