Optic Nerve Diseases (Optic Neuropathy)

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938 relevant articles (52 outcomes, 65 trials/studies) found for this Disease

Description: Conditions which produce injury or dysfunction of the second cranial or optic nerve, which is generally considered a component of the central nervous system. Damage to optic nerve fibers may occur at or near their origin in the retina, at the optic disk, or in the nerve, optic chiasm, optic tract, or lateral geniculate nuclei. Clinical manifestations may include decreased visual acuity and contrast sensitivity, impaired color vision, and an afferent pupillary defect.

Also Known As:

Optic Neuropathy; Optic Nerve Disease; Cranial Nerve II Disorder; Neural-Optical Lesion; Disk Disorder, Optic; Disk Disorders, Optic; Foster Kennedy Syndrome; Lesion, Neural-Optical; Lesions, Neural-Optical; Neural Optical Lesion; Neural-Optical Lesions; Neuropathies, Optic; Neuropathy, Optic; Optic Disk Disorder; Optic Neuropathies; Syndrome, Foster-Kennedy; Cranial Nerve II Diseases; Foster-Kennedy Syndrome; Optic Disk Disorders; Second Cranial Nerve Diseases

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 3643

Cranial Nerve Diseases: 155

Optic Nerve Diseases: 938

Optic Neuritis: 762

Papilledema: 407

Optic Atrophy: 378

Optic Nerve Injuries: 349

Ischemic Optic Neuropathy: 347

Optic Disk Drusen: 37

Optic Nerve Neoplasms: 1

Eye Diseases: 1323

Optic Nerve Diseases: 938

Optic Neuritis: 762

Papilledema: 407

Optic Atrophy: 378

Optic Nerve Injuries: 349

Ischemic Optic Neuropathy: 347

Optic Disk Drusen: 37

Optic Nerve Neoplasms: 1

Related Diseases

1.	Graves Ophthalmopathy
2.	Exophthalmos (Proptosis)
3.	Optic Neuritis (Retrobulbar Neuritis)
4.	Ischemic Optic Neuropathy (Anterior Ischemic Optic Neuropathy)
5.	Retinitis

Experts

1.	Foroozan, Rod: 4 articles (07/2007 - 03/2003)
2.	Sadun, Alfredo A: 3 articles (06/2007 - 05/2005)
3.	Perry, Julian D: 3 articles (05/2007 - 09/2003)
4.	Kim, Jae Ho: 3 articles (04/2007 - 05/2002)
5.	Brown, Stephen L: 3 articles (04/2007 - 05/2002)
6.	Kolozsvary, Andrew: 3 articles (04/2007 - 05/2002)
7.	Ryu, Samuel: 3 articles (04/2007 - 05/2002)
8.	Newman, N J: 3 articles (12/2004 - 05/2000)
9.	Saiz, A: 2 articles (10/2007 - 08/2007)
10.	Zoumalan, Christopher I: 2 articles (06/2007 - 05/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Optic Nerve Diseases:

1.	Retinaldehyde (Retinal)IBA 11/01/1982 - "Visual field changes were seen to be distinctive and, like electrophysiologic tests, were helpful in pointing to a retinal degenerative process rather than an optic neuropathy." 10/01/2008 - "CONCLUSIONS: This is the first study to produce measurements of the thickness of retinal peripapillary nerve fibers during optic neuropathies of NMO. " 08/01/2008 - "BACKGROUND AND PURPOSE: Our study aims to evaluate retinal function and neural conduction in post-retinal visual pathways of patients with non-arteritic ischaemic optic neuropathy (NION). " 05/01/2008 - "PURPOSE: To study the integrity of inner and outer retinal layers in patients with various types of optic neuropathy by using high-resolution imaging modalities. " 01/01/2006 - "PURPOSE: The goal of our study was to determine the value of electrophysiological tests in early and differential diagnosis of some hereditary retinal and optic nerve diseases. " Order ALL the reference details at left...
2.	OxygenIBA 08/01/1986 - "While hyperbaric oxygen is effective in the treatment of radiation-induced optic neuropathy, it must be instituted within several days of deterioration in vision for restoration of baseline function." 03/01/1994 - "Results suggest that hyperbaric oxygen might be a new remedy for the selected cases of non-arteritic ischaemic optic neuropathy and call for a controlled clinical study aiming to accurately assess its efficacy." 04/01/1991 - "A previously healthy 23-year-old male parachutist developed optic neuropathy after a series of multiple repeated hypobaric exposures; his symptoms improved promptly with recompression and hyperbaric oxygen therapy. " 11/01/2007 - "This, in turn, leads to unstable oxygen supply, which seems to be a relevant component in the pathogenesis of glaucomatous optic neuropathy." 03/01/2006 - "METHODS: MEDLINE searches were performed on radiation optic neuropathy, hyperbaric oxygen therapy, and similar terms, and selected references were reviewed. " Order ALL the reference details at left...
3.	Methylprednisolone FDA LinkGeneric 07/01/1989 - "Pulse methylprednisolone therapy appears to be beneficial in the initial management of severe dysthyroid optic neuropathy." 08/01/1999 - "OBJECTIVES: The study was carried out to assess the efficacy of megadose intravenous methylprednisolone in patients of bilateral simultaneous optic neuropathy (BSON) of unknown etiology. " 07/01/1989 - "Five patients with severe dysthyroid optic neuropathy were treated with intravenous methylprednisolone (1 g daily for 3 consecutive days). " 07/01/1989 - "Methylprednisolone pulse therapy in severe dysthyroid optic neuropathy." 05/01/2007 - "Dysthyroid optic neuropathy is best treated with intravenous pulsed methylprednisolone; if visual functions do not recover, urgent surgical decompression is indicated. " Order ALL the reference details at left...
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 09/01/1991 - "Radiotherapy resulted in significant improvement in subjective and objective signs of orbital congestion and was more effective than high-dose corticosteroids in relieving compressive optic neuropathy. " 12/01/2004 - "More randomized clinical trials are needed, especially to examine the role of orbital radiotherapy for severe thyroid-related orbitopathy characterized by severe congestion and/or compressive optic neuropathy with and without the use of corticosteroids. " 09/01/1986 - "The author suggests a trial of megadose, intravenous corticosteroids in patients between the ages of 21 and 45 years with optic neuropathies of uncertain or suspected autoimmune etiology after appropriate neuro-ophthalmologic evaluation." 12/01/2007 - "Conservative management, including intravenous corticosteroids, failed to resolve the patient's symptoms and compressive optic neuropathy. " 08/01/2004 - "He was diagnosed with retrobulbar optic neuropathy, and was started on a treatment of intravenous corticosteroids, showing no improvement. " Order ALL the reference details at left...
5.	linezolid (Zyvox)FDA Link 06/01/2005 - "Discontinuation of the linezolid therapy resulted in marked improvement of optic neuropathy. " 09/01/2006 - "CONCLUSIONS: Although daily-half doses of linezolid were effective in patients with intractable or extensive MDR-TB, this dosage regimen did not reduce long-term use-related side effects, such as peripheral and optic neuropathy." 07/01/2009 - "CONCLUSION: Our findings demonstrate that it is important for ophthalmologists as well as physicians and orthopedists to consider the possibility of optic neuropathy caused by long-term use of linezolid." 04/01/2009 - "After the discontinuation of linezolid treatment, both the optic neuropathy and visual impairment resolved without sequelae." 01/01/2008 - "Patients on long-term treatment with linezolid may develop an optic neuropathy (swollen or pale optic disc), symmetric painless decrease of visual acuity and colour vision, and bilateral visual field defects. " Order ALL the reference details at left...
6.	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 07/01/2009 - "Letter: Visual acuity improvement in acute non-arteritic anterior ischaemic optic neuropathy treated with intravitreal triamcinolone acetonide injection." 03/01/2009 - "Visual acuity improvement in acute non-arteritic anterior ischaemic optic neuropathy treated with intravitreal triamcinolone acetonide injection." 11/01/2008 - "We evaluated the role of intravitreal triamcinolone acetonide injection in eyes with non-arteritic anterior ischaemic optic neuropathy (NAION). " 11/01/2008 - "Intravitreal triamcinolone acetonide injection for acute non-arteritic anterior ischaemic optic neuropathy." Order ALL the reference details at left...
7.	Ethambutol (Myambutol)FDA LinkGeneric 03/01/1987 - "This study suggests that Arden contrast sensitivity plates would be effective in detecting subclinical toxic optic neuropathy due to ethambutol and therefore could be used for routine monitoring of ocular function of patients on ethambutol. " 01/01/1995 - "Thirty-six axial type ethambutol optic neuropathy patients, who visited our neuro-ophthalmology clinic from January, 1990, to December, 1993, were included in this study. " 11/01/1972 - "[Studies on the occurrence of optic nerve diseases in the course of myambutol therapy]" 05/01/2009 - "CONCLUSIONS: RNFL thickness associated with ethambutol optic neuropathy during the early stages was no different from the controls. " 05/01/2009 - "There was no significant difference between the RNFL thickness of the patients with the early stage of ethambutol optic neuropathy and those of the control group. " Order ALL the reference details at left...
8.	SteroidsIBA 07/01/1993 - "The patient responded to high-dose steroids with resolution of his optic neuropathy, marked decrease in the size of the mass, and resolution of the serum polyclonal gammopathy. " 06/01/2007 - "[Steroids for optic nerve diseases?]" 07/01/1986 - "The spectrum of clinical disease was variable but two groups could be identified: patients with chronic progressive visual loss which was associated with thickening of the optic nerve and was refractory to steroid treatment, and patients with acute or subacute optic neuropathy in which the visual loss responded rapidly to steroids. " 03/01/2007 - "Treatment with oral steroids followed by orbital wall decompression reversed the optic neuropathy. " 08/01/2006 - "More ophthalmologists chose surgical decompression for patients with threatened vision due to optic neuropathy, who were intolerant to steroids than other specialists (70.3 vs 41.8%, P<0.01). " Order ALL the reference details at left...
9.	CopperIBA 02/01/1998 - "Before attempting to use therapeutic copper to replenish endogenous stores in an attempt to preclude EMB-induced optic neuropathy, we wished to determine whether EMB is still effective against mycobacteria in the presence of copper. " 02/01/1998 - "This in vitro study suggests that if copper were given to patients to prevent EMB-induced optic neuropathy, it would not compromise EMB's bacteriostatic properties." 08/01/2009 - "CONCLUSIONS: Copper deficiency should be considered in cases of atypical optic neuropathy. " 08/01/2009 - "BACKGROUND: Acquired copper deficiency in adults is associated with a subacute to chronic progressive myeloneuropathy and optic neuropathy. " 08/01/2009 - "Acute and bilateral blindness due to optic neuropathy associated with copper deficiency." Order ALL the reference details at left...
10.	Triamcinolone (Aristocort)FDA Link 02/01/2009 - "PURPOSE: In this study, we aimed to evaluate the efficacy of peribulbar triamcinolone injections to treat inflammatory signs of Graves' ophthalmopathy (GO) in patients with moderate to severe GO and associated optic neuropathy (ON). " Order ALL the reference details at left...

Therapies and Procedures

1.	Decompression 02/01/1997 - "Orbital decompression has most commonly been performed for optic neuropathy, but with improved techniques, more patients are undergoing decompression for other indications. " 04/01/2005 - "CONCLUSION: Endoscopic medial orbital decompression is very effective in resolving compressive optic neuropathy. " 11/01/1990 - "Finally, we propose that optic nerve sheath decompression may be effective for what appear to be very different optic neuropathies because the operation may reverse optic nerve ischaemia, a common pathophysiologic feature of all these disorders." 08/01/2007 - "CONCLUSION: Endoscopic optic nerve decompression appears to be an effective treatment for restoring visual acuity in select patients who present with compressive optic neuropathy." 10/01/2005 - "CONCLUSIONS: Orbital decompression is a safe procedure and effective in improving vision in compressive optic neuropathy. " Order ALL the reference details at left...
2.	Drug Therapy (Chemotherapy) 11/01/2008 - "Early diagnosis and determination of the efficiency of drug therapy and indications for surgical treatment require that the presence and progression of optic neuropathy should be evaluated. " 04/01/2007 - "Immunosuppressive drug therapy may prevent recurrences of optic neuropathy and subsequent vision loss." 04/01/2007 - "No patients had recurrence of optic neuropathy while receiving immunosuppressive drug therapy. " 01/01/1996 - "CONCLUSION: Optic neuropathy and retinopathy are presumed to arise from the administration of a high-dose chemotherapy regimen. " 01/15/1999 - "Bilateral optic neuropathy with IgGkappa multiple myeloma improved after myeloablative chemotherapy." Order ALL the reference details at left...
3.	Aftercare (After-Treatment) 05/01/1999 - "Six months after treatment, the patient was doing well and showed no signs of radiation-induced optic neuropathy." 01/01/1990 - "The paper analyses results after treatment of 280 patients (467 eyes) with different forms of vascular optic neuropathies. " 02/01/1980 - "We measured pupil cycle time before and after treatment in 11 patients with compressive optic nerve disease. " 05/01/2008 - "After treatment of patients with optic neuropathy, visual acuity at last follow-up visit was improved in 5, worsened in 5, and stable (i.e., within one Snellen acuity line of baseline) in 4. CONCLUSION: In our Midwest retrospective case series of biopsy proven neuro-ophthalmic sarcoidosis, patients were predominately white females with a wide age range. " 06/01/2004 - "The case is presented of a 62-year-old man who developed radiation-induced optic neuropathy 2 years after treatment for a glioma of the left temporal lobe, despite being on anticoagulation therapy. " Order ALL the reference details at left...
4.	Injections 06/01/1996 - "Intravitreal injections of tumor necrosis factor-alpha (TNF alpha) induce morphological changes in the optic nerve suggesting a primary TNF alpha-induced optic neuropathy. " 02/01/2009 - "PURPOSE: In this study, we aimed to evaluate the efficacy of peribulbar triamcinolone injections to treat inflammatory signs of Graves' ophthalmopathy (GO) in patients with moderate to severe GO and associated optic neuropathy (ON). " 10/01/1997 - "To test the suppressive effects of pentoxifylline in preventing TNF-alpha-mediated axonal degeneration, we applied pentoxifylline to an established rabbit model that demonstrates an AIDS-like optic neuropathy using intravitreal TNF-alpha injections. " 01/01/1991 - "We recorded pattern electroretinograms, scotopic threshold responses, oscillatory potentials and ganzfeld flash electroretinograms in patients with glaucoma or other optic nerve diseases and in cats with inner retinal damage caused by intravitreal injections of kainic acid. " Order ALL the reference details at left...
5.	Investigational Therapies (Experimental Therapy) 01/01/2003 - "CONCLUSIONS: In addition to the application of this imaging method to studies of the effect on optic disc cupping of induced increased intraocular pressure in rats and mice, by detecting and documenting the onset and the course of optic neuropathy, it should be valuable in identifying animal models of glaucoma, in studying neuropathogenic mechanisms, and in assessing the effects of experimental therapies." Order ALL the reference details at left...

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