Abstract | BACKGROUND: METHODS: RESULTS: No significant associations were found between expression of Pgp, MRP1, MRP2, MRP3, ERCC1, or BRCA1 and either response or survival. However, there was a significant association between BCRP expression and both response (p=0.026) and progression-free survival (PFS; p=0.0103). CONCLUSIONS: BCRP expression was significantly predictive of both response and progression-free survival (PFS) in SCLC patients receiving chemotherapy. These findings suggest that BCRP may play a crucial role in drug resistance mechanisms, and that it may serve as an ideal molecular target for the treatment of SCLC.
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Authors | Young Hak Kim, Genichiro Ishii, Koichi Goto, Shuji Ota, Kaoru Kubota, Yukinori Murata, Michiaki Mishima, Nagahiro Saijo, Yutaka Nishiwaki, Atsushi Ochiai |
Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 65
Issue 1
Pg. 105-11
(Jul 2009)
ISSN: 1872-8332 [Electronic] Ireland |
PMID | 19036469
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ABCG2 protein, human
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters
- DNA-Binding Proteins
- Multidrug Resistance-Associated Proteins
- Neoplasm Proteins
- ERCC1 protein, human
- Endonucleases
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Topics |
- ATP Binding Cassette Transporter, Subfamily B, Member 1
(biosynthesis)
- ATP Binding Cassette Transporter, Subfamily G, Member 2
- ATP-Binding Cassette Transporters
(biosynthesis)
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Biopsy
- Carcinoma, Non-Small-Cell Lung
(drug therapy, metabolism, pathology)
- DNA-Binding Proteins
(biosynthesis)
- Endonucleases
(biosynthesis)
- Female
- Humans
- Immunohistochemistry
- Lung Neoplasms
(drug therapy, metabolism, pathology)
- Male
- Middle Aged
- Multidrug Resistance-Associated Proteins
(biosynthesis)
- Multivariate Analysis
- Neoplasm Proteins
(biosynthesis)
- Retrospective Studies
- Treatment Outcome
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