Paecilomyces lilacinus peritonitis complicating peritoneal dialysis cured by oral voriconazole and terbinafine combination therapy.

Abstract

Fungal peritonitis (FP) is a serious complication in patients on continuous ambulatory peritoneal dialysis (CAPD). We report a case of CAPD-related FP caused by Paecilomyces lilacinus in a 15-year-old uraemic boy. The infection was successfully treated by combination therapy consisting of oral voriconazole and terbinafine, which has not been previously reported in the treatment of FP.

• Authors: Brian Pin-Hsuan Chang, Pei-Lun Sun, Fu-Yuan Huang, Tsuen-Chiuan Tsai, Chun-Chen Lin, Ming-Dar Lee, Yee-Chun Chen, Jin-Cherng Sheu, Jeng-Daw Tsai
• Journal: Journal of medical microbiology (J Med Microbiol) Vol. 57 Issue Pt 12 Pg. 1581-1584 (Dec 2008) ISSN: 0022-2615 [Print] England
• PMID: 19018033 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antifungal Agents
• Naphthalenes
• Pyrimidines
• Triazoles
• Terbinafine
• Voriconazole

Topics

• Administration, Oral
• Adolescent
• Antifungal Agents (administration & dosage, therapeutic use)
• Drug Therapy, Combination
• Humans
• Male
• Mycoses (drug therapy, microbiology)
• Naphthalenes (administration & dosage, therapeutic use)
• Paecilomyces (drug effects, isolation & purification)
• Peritoneal Dialysis, Continuous Ambulatory (adverse effects)
• Peritonitis (drug therapy, microbiology)
• Pyrimidines (administration & dosage, therapeutic use)
• Terbinafine
• Treatment Outcome
• Triazoles (administration & dosage, therapeutic use)
• Voriconazole