Abstract | BACKGROUND: METHODS: RESULTS: The trial was stopped after a median follow-up of 1.9 years (maximum, 5.0). Rosuvastatin reduced LDL cholesterol levels by 50% and high-sensitivity C-reactive protein levels by 37%. The rates of the primary end point were 0.77 and 1.36 per 100 person-years of follow-up in the rosuvastatin and placebo groups, respectively (hazard ratio for rosuvastatin, 0.56; 95% confidence interval [CI], 0.46 to 0.69; P<0.00001), with corresponding rates of 0.17 and 0.37 for myocardial infarction (hazard ratio, 0.46; 95% CI, 0.30 to 0.70; P=0.0002), 0.18 and 0.34 for stroke (hazard ratio, 0.52; 95% CI, 0.34 to 0.79; P=0.002), 0.41 and 0.77 for revascularization or unstable angina (hazard ratio, 0.53; 95% CI, 0.40 to 0.70; P<0.00001), 0.45 and 0.85 for the combined end point of myocardial infarction, stroke, or death from cardiovascular causes (hazard ratio, 0.53; 95% CI, 0.40 to 0.69; P<0.00001), and 1.00 and 1.25 for death from any cause (hazard ratio, 0.80; 95% CI, 0.67 to 0.97; P=0.02). Consistent effects were observed in all subgroups evaluated. The rosuvastatin group did not have a significant increase in myopathy or cancer but did have a higher incidence of physician-reported diabetes. CONCLUSIONS:
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Authors | Paul M Ridker, Eleanor Danielson, Francisco A H Fonseca, Jacques Genest, Antonio M Gotto Jr, John J P Kastelein, Wolfgang Koenig, Peter Libby, Alberto J Lorenzatti, Jean G MacFadyen, Børge G Nordestgaard, James Shepherd, James T Willerson, Robert J Glynn, JUPITER Study Group |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 359
Issue 21
Pg. 2195-207
(Nov 20 2008)
ISSN: 1533-4406 [Electronic] United States |
PMID | 18997196
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | 2008 Massachusetts Medical Society |
Chemical References |
- Biomarkers
- Cholesterol, LDL
- Fluorobenzenes
- Glycated Hemoglobin A
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Pyrimidines
- Sulfonamides
- Rosuvastatin Calcium
- C-Reactive Protein
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Topics |
- Aged
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Cardiovascular Diseases
(blood, mortality, prevention & control)
- Cholesterol, LDL
(blood)
- Diabetes Mellitus
(chemically induced)
- Double-Blind Method
- Female
- Fluorobenzenes
(adverse effects, therapeutic use)
- Follow-Up Studies
- Glycated Hemoglobin
(metabolism)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(adverse effects, therapeutic use)
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Muscular Diseases
(chemically induced)
- Myocardial Infarction
(epidemiology, prevention & control)
- Proportional Hazards Models
- Pyrimidines
(adverse effects, therapeutic use)
- Rosuvastatin Calcium
- Stroke
(epidemiology, prevention & control)
- Sulfonamides
(adverse effects, therapeutic use)
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