Topical anti-inflammatory activity of dianemycin isolated fromStreptomyces sp. MT 2705-4.

Abstract

In order to develop new anti-inflammatory agents having different action mechanisms compared with nonsteroidal and steroidal anti-inflammatory drugs, the culture broths of various actinomycetes isolated from soil were screened using anin vivo mouse ear edma assay and one strain (Streptomyces sp. MT 2705-4: KCTC 8651P) was selected. Activity-guided purification led to the isolation of a polyether compound, dianemycin. Topically, dianemycin showed a potent anti-inflammatory activity in mouse ear edema induced by croton-oil or arachidonic acid. ED(50) value of dianemycin was found to be 0.8 mg/ear compared to 0.4 mg/ear of prednisolone in croton-oil ear edema. However, dianemycin did not show the inhibitory activity in UV-erythema and delayed hypersensitivity reaction. These results indicate that dianemycin is a potential topical anti-inflammatory agent.

• Authors: S J Lee, H P Kim, B K Park, S C Ahn, H S Lee, J S Ahn
• Journal: Archives of pharmacal research (Arch Pharm Res) Vol. 20 Issue 4 Pg. 372-4 (Aug 1997) ISSN: 0253-6269 [Print] Korea (South)
• PMID: 18975182 (Publication Type: Journal Article)