Cytotoxic beta-dihydroagarofuran sesquiterpenoids from the fruits of Celastrus orbiculatus.

Abstract

Assay-guided fractionation led to the isolation of nine beta-dihydroagarofuran sesquiterpenoids from the fruits of Celastrus orbiculatus. All isolated beta-dihydroagarofuran sesquiterpenoids were tested for their cytotoxic activity against human melanoma A375-S2 and human cervical carcinoma Hela cell lines. Among them, compounds 1-5 and 7 showed cytotoxic activity. Compound 3 exhibited promising cytotoxicity against both human melanoma A375-S2 and human cervical carcinoma Hela cell lines. The structure-activity relationship was discussed briefly.

• Authors: Jing Xu, Yuan-Qiang Guo, Xian Li, Kun Wei, Xiaojun Zhao, Shuzhong Zhang
• Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences (Z Naturforsch C J Biosci) 2008 Jul-Aug Vol. 63 Issue 7-8 Pg. 515-8 ISSN: 0939-5075 [Print] Germany
• PMID: 18810994 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Sesquiterpenes
• dihydroagarofuran

Topics

• Antineoplastic Agents, Phytogenic (pharmacology)
• Cell Line, Tumor
• Chromatography, High Pressure Liquid
• Drug Screening Assays, Antitumor
• Humans
• Magnetic Resonance Spectroscopy
• Sesquiterpenes (pharmacology)
• Structure-Activity Relationship