[Juvenile laryngeal papillomatosis--immunisation with the polyvalent vaccine gardasil].

Abstract

Juvenile laryngeal papillomatosis is a rare condition caused by human papilloma virus (HPV). In cases with rapid recurrences permanent impairments of voice and breathing are almost inevitable due to the frequent need of debulking surgeries. Efforts to lower the recurrence rate comprise the adjuvant use of interferon alpha, local cidofovir, photodynamic therapy or mumps vaccination. In the present case we tried to positively influence the aggressive course of disease in a two year old boy by immunisation with the quadrivalent HPV vaccine Gardasil(R). Chromogenic in-situ hybridisation analysis and polymerase chain reaction (PCR) of lesion tissue showed simultaneous infection with the HPV-Types 6 and 11. After the third immunisation the disease became stable. No further surgery was necessary for the last ten months. The risk profile of this adjuvant treatment is low. We think it worth to initiate a multicentre trial to prove a benefit of this treatment even if no complete virus elimination can be achieved.

• Authors: G Förster, C Boltze, J Seidel, M Pawlita, A Müller
• Journal: Laryngo- rhino- otologie (Laryngorhinootologie) Vol. 87 Issue 11 Pg. 796-9 (Nov 2008) ISSN: 0935-8943 [Print] Germany
• Vernacular Title: Juvenile Larynxpapillomatose--Impfung mit dem polyvalenten Spaltimpfstoff Gardasil.
• PMID: 18759217 (Publication Type: Case Reports, Comparative Study, English Abstract, Journal Article)

Chemical References

• Antibodies, Viral
• Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
• Papillomavirus Vaccines

Topics

• Alphapapillomavirus (immunology)
• Antibodies, Viral (blood)
• Fluorescence
• Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
• Human papillomavirus 11 (immunology)
• Human papillomavirus 6 (immunology)
• Humans
• Immunization
• In Situ Hybridization
• Infant
• Laryngeal Neoplasms (diagnosis, immunology, therapy, virology)
• Male
• Neoplasm Recurrence, Local (prevention & control)
• Papilloma (diagnosis, immunology, therapy, virology)
• Papillomavirus Vaccines (administration & dosage, immunology)
• Polymerase Chain Reaction
• Time Factors