Abstract | PROBLEM: METHOD OF STUDY: This cross-sectional study included normal pregnant women (n = 187) and patients with pre-eclampsia (n = 99). Maternal plasma MBL concentrations were determined by ELISA. RESULTS: Women with pre-eclampsia had a higher median maternal plasma MBL concentration than normal pregnant women. MBL concentration distribution curves were three-modal, the subintervals in normal pregnancy were low (< 143.7), intermediate (143.7-1898.9) and high (> 1898.9 ng/mL). The proportion of normal pregnant women was larger in the low subinterval, while the proportion of patients with preeclampsia was larger in the high subinterval (P = 0.02). Normal pregnant women in the high subinterval had a larger rate of placental underperfusion than those in the low and intermediate subintervals (P = 0.02). CONCLUSIONS: The median maternal plasma MBL concentration is elevated in patients with pre-eclampsia and a larger proportion of these patients are in the high subinterval than normal pregnant women, suggesting that this component of the innate immune system is involved in the mechanisms of disease in pre-eclampsia.
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Authors | Nandor Gabor Than, Roberto Romero, Offer Erez, Juan Pedro Kusanovic, Adi L Tarca, Samuel S Edwin, Jung-Sun Kim, Sonia S Hassan, Jimmy Espinoza, Pooja Mittal, Shali Mazaki-Tovi, Lara Friel, Francesca Gotsch, Edi Vaisbuch, Natalia Camacho, Zoltan Papp |
Journal | American journal of reproductive immunology (New York, N.Y. : 1989)
(Am J Reprod Immunol)
Vol. 60
Issue 4
Pg. 333-45
(Oct 2008)
ISSN: 1046-7408 [Print] Denmark |
PMID | 18727690
(Publication Type: Journal Article, Research Support, N.I.H., Intramural)
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Chemical References |
- MBL2 protein, human
- Mannose-Binding Lectin
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Topics |
- Adult
- Cross-Sectional Studies
- Female
- Genetic Predisposition to Disease
- Humans
- Immunity, Innate
- Mannose-Binding Lectin
(blood, genetics, immunology)
- Pre-Eclampsia
(blood, genetics, immunology)
- Pregnancy
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