Midkine as a prognostic biomarker in oral squamous cell carcinoma.
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| Abstract |
The aim of this study was to evaluate serum midkine (S-MK) concentrations as a prognostic tumour marker in oral squamous cell carcinoma (OSCC). We measured S-MK concentrations in patients with OSCC and healthy volunteers. In addition, we performed real-time quantitative reverse transcription-PCR analysis and immunohistochemistry with fresh tumour samples. To determine whether S-MK concentrations have prognostic value, we performed survival analyses with clinical information by using the log-rank test. Serum midkine concentrations were significantly higher in patients with OSCC than in healthy controls (P<0.001). Serum midkine concentrations were also significantly increased in early-stage OSCC compared with those of healthy individuals (P<0.001). In addition, immunohistochemistry allowed identification of overexpressed MK protein in OSCC tissues. MK mRNA showed higher expression in OSCC samples compared with normal mucosal samples. Patients in high S-MK groups showed a significantly lower 5-year survival rate compared with patients in low S-MK groups (P<0.05). The increased S-MK concentrations in early-stage OSCC were strongly associated with poor survival. Serum midkine concentrations may thus be a useful marker not only for cancer screening but also for predicting prognosis of OSCC patients.
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| Authors | K Ota, H Fujimori, M Ueda, S Shiniriki, M Kudo, H Jono, Y Fukuyoshi, Y Yamamoto, H Sugiuchi, H Iwase, M Shinohara, Y Ando |
| Journal | British journal of cancer (Br J Cancer) Vol. 99 Issue 4 Pg. 655-62 (Aug 19 2008) ISSN: 1532-1827 [Electronic] England |
| PMID | 18682710 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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