Abstract | PURPOSE:
Cannabidiol (CBD), a nonpsychotropic, nontoxic compound has been shown to block diabetes- and endotoxin-induced retinal damage. However, the protective mechanism of this anti-inflammatory cannabinoid is not completely understood. The goal of this study is to determine the role of adenosine signaling in retinal inflammation and its potential modulation by CBD. METHODS: RESULTS: CONCLUSIONS: These results suggest that the activated A(2A)AR in the retinal microglial cells plays a major anti-inflammatory role in the retina and that CBD's anti-inflammatory effects are linked to the inhibition of adenosine uptake.
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Authors | Gregory I Liou, John A Auchampach, Cecilia J Hillard, Gu Zhu, Bilal Yousufzai, Salman Mian, Sohail Khan, Yousuf Khalifa |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 49
Issue 12
Pg. 5526-31
(Dec 2008)
ISSN: 1552-5783 [Electronic] United States |
PMID | 18641283
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adenosine A2 Receptor Agonists
- Adenosine A2 Receptor Antagonists
- Anti-Inflammatory Agents
- Lipopolysaccharides
- Nucleoside Transport Proteins
- RNA, Messenger
- Receptor, Adenosine A2A
- Tumor Necrosis Factor-alpha
- Cannabidiol
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Topics |
- Adenosine A2 Receptor Agonists
- Adenosine A2 Receptor Antagonists
- Animals
- Anti-Inflammatory Agents
(pharmacology)
- Cannabidiol
(pharmacology)
- Cells, Cultured
- Enzyme-Linked Immunosorbent Assay
- Lipopolysaccharides
(pharmacology)
- Male
- Microglia
(drug effects, metabolism)
- Nucleoside Transport Proteins
(metabolism)
- RNA, Messenger
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Receptor, Adenosine A2A
(metabolism)
- Retina
(drug effects, metabolism)
- Reverse Transcriptase Polymerase Chain Reaction
- Salmonella enterica
- Tumor Necrosis Factor-alpha
(metabolism)
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