Cannabidiol

11/16/2023 - "Efficacy of highly purified cannabidiol (CBD) in typical absence seizures: A pilot study."
12/01/2018 - "Recently, cannabidiol has provided high evidence of efficacy against LGS seizures; however, these data must be confirmed by long-term extensive studies and by trials comparing different AEDs, one to each other."
01/01/2022 - "Cannabidiol pre-treated rats showed a significant reduction in duration and severity of seizures, and IL-1β levels, although the latency, incidence of seizures, and mortality rate remained unchanged as well the quantification of microglia in the selected areas. "
01/01/2017 - "The frequency of total seizures of all types was significantly reduced with cannabidiol (P=0.03), but there was no significant reduction in nonconvulsive seizures. "
12/01/2020 - "The introduction of CBD as the medicine Epidiolex in the United States (in 2018) and as Epidyolex in the European Union (in 2019) as the first cannabis-derived therapeutic for the treatment of seizures was underpinned by preclinical research performed at the University of Reading. "

01/01/2023 - "The non-euphorigenic phytocannabinoid cannabidiol (CBD) has been used successfully to treat childhood-onset epilepsies. "
11/01/2016 - "Preliminary data from human studies suggest that cannabis, cannabidiol in particular, is effective in the treatment of some patients with epilepsy. "
01/01/2023 - "Cannabidiol is effective in people with epilepsy. "
01/01/2022 - "Cannabidiol (CBD) has been effective for use as an adjunctive treatment for two severe pediatric seizure disorders. "
01/01/2019 - "The recent US Food and Drug Administration approval of the marijuana constituent cannabidiol as safe and effective for treatment of 2 rare forms of epilepsy has raised hopes that others of the 500 chemicals in marijuana will be found to be therapeutic. "

01/01/2022 - "Buccally Absorbed Cannabidiol Shows Significantly Superior Pain Control and Improved Satisfaction Immediately After Arthroscopic Rotator Cuff Repair: A Placebo-Controlled, Double-Blinded, Randomized Trial."
12/01/2020 - "In one study, cannabidiol (CBD) significantly improved the pain intensity compared to placebo (P < 0.001). "
04/18/2023 - "Cannabidiol Treatment Shows Therapeutic Efficacy in a Rodent Model of Social Transfer of Pain in Pair-Housed Male Mice."
01/01/2017 - "Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats."
10/01/2019 - "In contrast, cannabidiol (CBD) levels generally were not associated with pain relief except for a negative association between CBD and relief from gastrointestinal and non-specified pain. "

11/01/2023 - "Highly purified cannabidiol (CBD) has a broad spectrum of action and could be useful for the treatment of drug resistant epilepsy regardless of etiology or syndrome. "
01/01/2021 - "Long-term safety and efficacy of highly purified cannabidiol for treatment refractory epilepsy."
01/01/2019 - "Over a 4-year period, cannabidiol was effective in 26.9% of children with otherwise refractory epilepsy. "
11/01/2022 - "Artisanal cannabidiol-enriched cannabis may be an effective and safe long-term treatment for refractory epilepsy."
09/21/2021 - "During a phase II expanded access program (EAP) study to evaluate the safety and efficacy of using cannabidiol (CBD) for the long-term treatment of children with drug-resistant epilepsy, secondary outcome measures were also performed, including quality of life (QOLCE), behavior (aberrant behavior checklist ABC), and sleep (children's sleep habit questionnaire, CSHQ). "

06/01/2020 - "Introduction: Highly purified cannabidiol (CBD) (approved as Epidiolex® in the United States) has demonstrated efficacy with an acceptable safety profile in patients with Lennox-Gastaut or Dravet syndrome in four randomized controlled trials. "
01/01/2020 - "Highly purified cannabidiol (CBD) (approved as Epidiolex® in the United States and as EPIDYOLEX from the EU agency) has demonstrated efficacy with an acceptable safety profile in patients with Lennox-Gastaut or Dravet syndrome in four randomized controlled trials. "
12/06/2021 - "In conclusion, cannabidiol is associated with clinical improvement in Dravet syndrome. "
01/01/2020 - "Cannabidiol treatment reduced premature mortality and improved several behavioural co-morbidities in Dravet syndrome mice. "
01/01/2020 - "The efficacy of sub-chronic cannabidiol administration in two mouse models of Dravet syndrome was investigated. "