Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: The combined use of 5'-dFUrd and paclitaxel showed additive to synergistic antitumor effects on both gastric cancer xenografts. There were significant differences of the gene expressions of dThdPase, TS, and DPD between the xenografts. The expression of dThdPase mRNA was consistently up-regulated by the administration of paclitaxel, while no constant direction of TS mRNA and DPD mRNA change was found in the xenografts. CONCLUSION: A synergistic antitumor effect of the combined administration of 5'-dFUrd and paclitaxel was found in gastric cancer xenografts and up-regulation of dThdPase mRNA may be an important underlying mechanism especially in tumors with high gene expression of this enzyme.
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Authors | Yoichi Sakurai, Ikuo Yoshida, Shingo Kamoshida, Kazuki Inaba, Jun Isogaki, Yoshiyuki Komori, Ichiro Uyama, Yutaka Tsutsumi |
Journal | Anticancer research
(Anticancer Res)
2008 May-Jun
Vol. 28
Issue 3A
Pg. 1593-602
ISSN: 0250-7005 [Print] Greece |
PMID | 18630517
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- Floxuridine
- Dihydrouracil Dehydrogenase (NADP)
- Thymidylate Synthase
- Thymidine Phosphorylase
- Paclitaxel
- doxifluridine
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Topics |
- Animals
- Antineoplastic Combined Chemotherapy Protocols
(pharmacokinetics, pharmacology)
- Body Weight
- Dihydrouracil Dehydrogenase (NADP)
(biosynthesis, genetics, metabolism)
- Floxuridine
(administration & dosage, pharmacokinetics, pharmacology)
- Gene Expression
(drug effects)
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Paclitaxel
(administration & dosage, pharmacokinetics, pharmacology)
- RNA, Messenger
(biosynthesis, genetics)
- Stomach Neoplasms
(drug therapy, enzymology, genetics)
- Thymidine Phosphorylase
(biosynthesis, genetics, metabolism)
- Thymidylate Synthase
(biosynthesis, genetics, metabolism)
- Xenograft Model Antitumor Assays
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