Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: In white patients, multilocus interactions in maternal DNA between single nucleotide polymorphisms at -7227 (interleukin-6), 22,215 (interleuki-6 receptor) and -3448 ( tumor necrosis factor-alpha) was predictive of approximately 59.1% (P < .02; odds ratio, 2.3 [95% confidence interval = 1.6-3.4]) of pregnancy outcome. In white fetal DNA and black maternal DNA, no significant interactive models were observed. In black patients, the best epistatic model was in fetal DNA between single nucleotide polymorphisms at 17,691 ( tumor necrosis factor-receptor 1) and at -3448 ( tumor necrosis factor-alpha) and was predictive of pregnancy outcome 68.3% of the time (P < .01; odds ratio, 5.0 [95% confidence interval = 2.6-9.6]). CONCLUSION: Analyses of multilocus interactions found/associated different models in black and white patients in both maternal and fetal DNA with preterm birth as outcome. Significant maternal-fetal interactions were not detected in either race.
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Authors | Stephen J Fortunato, Ramkumar Menon, Digna R Velez, Poul Thorsen, Scott M Williams |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 198
Issue 6
Pg. 666.e1-9; discussion 666.e9-10
(Jun 2008)
ISSN: 1097-6868 [Electronic] United States |
PMID | 18538149
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-6
- Receptors, Interleukin-6
- Receptors, Tumor Necrosis Factor, Type I
- Receptors, Tumor Necrosis Factor, Type II
- Tumor Necrosis Factor-alpha
- DNA
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Topics |
- Adult
- Black People
(genetics)
- DNA
(genetics)
- Epistasis, Genetic
- Female
- Humans
- Interleukin-6
(genetics)
- Polymorphism, Single Nucleotide
- Pregnancy
- Pregnancy Outcome
- Premature Birth
(ethnology, genetics)
- Receptors, Interleukin-6
(genetics)
- Receptors, Tumor Necrosis Factor, Type I
(genetics)
- Receptors, Tumor Necrosis Factor, Type II
(genetics)
- Tumor Necrosis Factor-alpha
(genetics)
- White People
(genetics)
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