Sinonasal undifferentiated carcinoma with a frozen globe.

Abstract

A 42-year-old previously healthy woman presented with a 5-week history of headache, facial numbness, proptosis, motility restriction, and visual loss. CT showed soft-tissue infiltration involving the posterior ethmoids, pterygopalatine fossa, and posterior inferior orbit. Histopathologic analysis of a biopsy specimen disclosed a highly aggressive and undifferentiated neoplasm with an immunophenotype and ultrastructural features consistent with an epithelial origin, which was most consistent with a diagnosis of sinonasal indifferentiated carcinoma. The tumor was unresectable and the patient was started on a course of radiation and chemotherapy.

• Authors: Pete H Spitellie, David R Jordan, Seymour Brownstein, Patrick Gooi, Bruce Burns
• Journal: Ophthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) 2008 May-Jun Vol. 24 Issue 3 Pg. 225-7 ISSN: 0740-9303 [Print] United States
• PMID: 18520842 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Biopsy
• Carcinoma (diagnostic imaging, drug therapy, pathology, radiotherapy)
• Female
• Humans
• Neoplasm Invasiveness
• Orbital Neoplasms (diagnostic imaging, drug therapy, pathology, radiotherapy)
• Paranasal Sinus Neoplasms (diagnostic imaging, drug therapy, pathology, radiotherapy)
• Tomography, X-Ray Computed