Abstract | BACKGROUND: OBJECTIVES AND METHODS: RESULTS: The difference between height and target height and between predicted adult height and target height did not differ between the groups, indicating preservation of height potential. The groups had comparable bone age, but bone age was lower than chronological age in girls with anorexia nervosa. Girls with anorexia nervosa had lower insulin-like growth factor 1 levels and higher nadir growth hormone levels than those of controls. Nadir growth hormone levels predicted height SD scores and predicted adult-height SD scores in controls but not in the girls with anorexia nervosa. In girls with anorexia nervosa, insulin-like growth factor 1 and duration of illness predicted height measures. Height SD scores of <0 were more likely after 32 months of illness and at insulin-like growth factor 1 levels of <134 ng/mL. Delayed baseline bone age predicted subsequent increases in height SD scores in immature girls with anorexia nervosa. CONCLUSIONS: Our data suggest that preservation of height potential in this cohort of girls with anorexia nervosa may be a consequence of delayed bone age. Hypogonadism may negate the deleterious effects of undernutrition on stature by allowing for a longer duration of growth.
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Authors | Rajani Prabhakaran, Madhusmita Misra, Karen K Miller, Kimberly Kruczek, Shankeertha Sundaralingam, David B Herzog, Debra K Katzman, Anne Klibanski |
Journal | Pediatrics
(Pediatrics)
Vol. 121
Issue 6
Pg. e1517-23
(Jun 2008)
ISSN: 1098-4275 [Electronic] United States |
PMID | 18519455
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Insulin-Like Growth Factor Binding Protein 1
- Growth Hormone
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Topics |
- Adolescent
- Anorexia Nervosa
(physiopathology)
- Body Height
- Bone and Bones
(physiopathology)
- Child
- Female
- Growth Hormone
(physiology)
- Growth Plate
(physiopathology)
- Humans
- Insulin-Like Growth Factor Binding Protein 1
(physiology)
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