Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells.

Abstract

OBJECTIVES:

To observe the anti-tumor activities of honokiol on human ovarian tumor in vitro and in vivo.

STUDY DESIGN:

Cells were treated with honokiol, and the effects on proliferation and apoptosis were examined by MTT, DNA ladder, Hoechst staining, and flow cytometry assays. Expression of Bcl-2 members and caspase-3 were assessed. Measurements of tumor volume and microvessel densities (MVDs) were performed.

RESULTS:

Honokiol significantly inhibited proliferation and induced apoptosis, with alteration of Bcl-2 members and caspase-3. Administration of honokiol to tumor-bearing animals decreased MVD and resulted in inhibition of tumor growth.

CONCLUSIONS:

Honokiol could induce apoptosis and inhibit angiogenesis in vitro and in vivo, suggesting a novel and attractive therapeutic candidate for ovarian tumor treatment.

• Authors: Zhengyu Li, Yi Liu, Xia Zhao, Xiaoling Pan, Rutie Yin, Canhua Huang, Lijuan Chen, Yuquan Wei
• Journal: European journal of obstetrics, gynecology, and reproductive biology (Eur J Obstet Gynecol Reprod Biol) Vol. 140 Issue 1 Pg. 95-102 (Sep 2008) ISSN: 0301-2115 [Print] Ireland
• PMID: 18440692 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inhibitors
• Biphenyl Compounds
• Lignans
• honokiol

Topics

• Angiogenesis Inhibitors (pharmacology)
• Animals
• Apoptosis (drug effects)
• Biphenyl Compounds (pharmacology)
• Cell Line, Tumor (drug effects)
• Disease Models, Animal
• Female
• Humans
• Lignans (pharmacology)
• Mice
• Mice, Nude
• Neovascularization, Pathologic (drug therapy)
• Ovarian Neoplasms (drug therapy)