Abstract | OBJECTIVE: METHODS: RESULTS:
Autoantibodies to TIA-1 and/or TIAR were detected in 61% of patients with systemic lupus erythematosus (SLE), 42% of patients with systemic sclerosis (SSc), 15-31% of patients with other rheumatic diseases, and 6% of healthy controls. Compared with patients negative for anti-TIA antibody, anti-TIA antibody-positive SLE patients had higher disease activity (P = 0.01), elevated antibodies to double-stranded DNA (P = 0.0003), and increased serum TNFalpha levels (P = 0.018). In SLE patients, anti-TIAR antibodies were associated with lupus nephritis (P = 0.02), while in patients with SSc, anti-TIA-1 was associated with lung involvement (P = 0.02). Immunohistochemical analysis of skin and kidney tissue revealed aberrant expression of TIA proteins in skin lesions from SLE and SSc patients, as well as in glomerular cells from SLE patients. CONCLUSION: Aberrant expression of TIA proteins in inflammatory tissue may lead to systemic autoantibody responses, particularly in SLE and SSc. Increased occurrence of anti-TIA autoantibodies in patients with severe organ involvement may point to a possible pathogenetic role.
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Authors | Esther Jimenez-Boj, Nancy Kedersha, Makiyeh Tohidast-Akrad, Franz M Karlhofer, Georg Stummvoll, Christof Zimmermann, Walter Ulrich, Serena Guiducci, Elisabeth Hoefler, Martin Aringer, Georg Schett, Marco Matucci-Cerinic, Josef S Smolen, Günter Steiner |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 58
Issue 5
Pg. 1226-36
(May 2008)
ISSN: 0004-3591 [Print] United States |
PMID | 18438838
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Poly(A)-Binding Proteins
- RNA-Binding Proteins
- T-Cell Intracellular Antigen-1
- TIA1 protein, human
- TIAL1 protein, human
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Topics |
- Autoantibodies
(blood)
- Humans
- Lupus Erythematosus, Systemic
(blood, diagnosis, immunology)
- Poly(A)-Binding Proteins
(immunology)
- RNA-Binding Proteins
(immunology)
- Scleroderma, Systemic
(blood, diagnosis, immunology)
- T-Cell Intracellular Antigen-1
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