Treatment of pemphigus vulgaris with mycophenolate mofetil as a steroid-sparing agent.
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| Abstract |
Pemphigus vulgaris is a rare autoimmune blistering disease. Estimation of the incidence in Iran is one patient per 100,000 of the population per year. Mycophenolate mofetil is an immunosuppressive drug and successful treatment of pemphigus vulgaris and bullous pemphigoid has been reported with it, in combination with high dose prednisone, or as monotherapy. The present study describes our experience of the adjuvant use of mycophenolate mofetil in the management of 31 patients with pemphigus vulgaris as an initial treatment. We evaluated the efficacy and safety of mycophenolate mofetil combined with prednisolone in this cohort. We also assessed the relationship between the demographic indices/disease severity factors, and the failure of this treatment. In this study, mycophenolate mofetil was of definite benefit in 21 cases (67.7%). Generalized forms; patients with higher sum of the clinical scores at presentation; severe involvement of the groin; chest; face and limbs and those who had nail dystrophy also appeared to have poorer responses. When we excluded patients with generalized forms, only four patients were included in the failure group and the response rate reached 83.3%. It can be concluded that, except for generalized diseases, mycophenolate mofetil can be used safely and effectively in patients with pemphigus vulgaris as a first line, steroid sparing agent.
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| Authors | Nafiseh Esmaili, Cheyda Chams-Davatchi, Mahin Valikhani, Farshad Farshidfar, Nima Parvaneh, Banafshe Tamizifar |
| Journal | European journal of dermatology : EJD (Eur J Dermatol) 2008 Mar-Apr Vol. 18 Issue 2 Pg. 159-64 ISSN: 1167-1122 [Print] France |
| PMID | 18424375 (Publication Type: Clinical Trial, Journal Article) |
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