Abstract | PURPOSE: METHODS AND MATERIALS: RESULTS:
Tumor growth analyses show that radiotherapy synergizes with FTHI in antihapten-immunized mice, thereby allowing for cures of animals bearing tumors greater than 300 mm(3). More importantly, nonirradiated distal tumor masses in animals containing locally irradiated tumors also showed improved response to hapten immunotherapy, suggesting that not all tumor lesions must be identified and irradiated to benefit from the combination therapy. CONCLUSIONS: These results suggest that simultaneous treatment with FTHI and radiation therapy can enhance systemic antitumor activity in tumor-bearing mice.
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Authors | Emanuela I Sega, Yingjuan Lu, Michael Ringor, Christopher P Leamon, Philip S Low |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 71
Issue 2
Pg. 559-66
(Jun 01 2008)
ISSN: 0360-3016 [Print] United States |
PMID | 18411004
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Carrier Proteins
- Folate Receptors, GPI-Anchored
- Haptens
- Interleukin-2
- Neoplasm Proteins
- Receptors, Cell Surface
- Interferon-gamma
- Folic Acid
- Fluorescein-5-isothiocyanate
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Topics |
- Animals
- Antineoplastic Agents
(therapeutic use)
- Carrier Proteins
(immunology)
- Combined Modality Therapy
(methods)
- Female
- Fluorescein-5-isothiocyanate
(therapeutic use)
- Folate Receptors, GPI-Anchored
- Folic Acid
(therapeutic use)
- Haptens
(immunology, therapeutic use)
- Humans
- Immunotherapy
(methods)
- Interferon-gamma
(therapeutic use)
- Interleukin-2
(therapeutic use)
- Mice
- Mice, Inbred BALB C
- Neoplasm Proteins
(immunology)
- Radiotherapy
(methods)
- Radiotherapy Dosage
- Random Allocation
- Receptors, Cell Surface
(immunology)
- Skin Neoplasms
(immunology, pathology, radiotherapy, therapy)
- Tumor Burden
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