Diagnostic accuracy of urinary spot protein:creatinine ratio for proteinuria in hypertensive pregnant women: systematic review.

Abstract

OBJECTIVE:

To review the spot protein:creatinine ratio and albumin:creatinine ratio as diagnostic tests for significant proteinuria in hypertensive pregnant women.

DESIGN:

Systematic review.

DATA SOURCES:

Medline and Embase, the Cochrane Library, reference lists, and experts. Review methods Literature search (1980-2007) for articles of the spot protein:creatinine ratio or albumin:creatinine ratio in hypertensive pregnancy, with 24 hour proteinuria as the comparator.

RESULTS:

13 studies concerned the spot protein:creatinine ratio (1214 women with primarily gestational hypertension). Nine studies reported sensitivity and specificity for eight cut-off points, median 24 mg/mmol (range 17-57 mg/mmol; 0.15-0.50 mg/mg). Laboratory assays were not well described. Diagnostic test characteristics were recalculated for a cut-off point of 30 mg/mmol. No significant heterogeneity in cut-off points was found between studies over a range of proteinuria. Pooled values gave a sensitivity of 83.6% (95% confidence interval 77.5% to 89.7%), specificity of 76.3% (72.6% to 80.0%), positive likelihood ratio of 3.53 (2.83 to 4.49), and negative likelihood ratio of 0.21 (0.13 to 0.31) (nine studies, 1003 women). Two studies of the spot albumin:creatinine ratio (225 women) found optimal cut-off points of 2 mg/mmol for proteinuria of 0.3 g/day or more and 27 mg/mmol for albuminuria.

CONCLUSION:

The spot protein:creatinine ratio is a reasonable "rule-out" test for detecting proteinuria of 0.3 g/day or more in hypertensive pregnancy. Information on use of the albumin:creatinine ratio in these women is insufficient.

• Authors: Anne-Marie Côté, Mark A Brown, Elaine Lam, Peter von Dadelszen, Tabassum Firoz, Robert M Liston, Laura A Magee
• Journal: BMJ (Clinical research ed.) (BMJ) Vol. 336 Issue 7651 Pg. 1003-6 (May 03 2008) ISSN: 1756-1833 [Electronic] England
• PMID: 18403498 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't, Review, Systematic Review, Validation Study)

Chemical References

• Reagent Strips
• Creatinine

Topics

• Albuminuria (etiology)
• Creatinine (urine)
• Diagnostic Tests, Routine (methods, standards)
• Female
• Humans
• Hypertension, Pregnancy-Induced (urine)
• Pregnancy
• Proteinuria (etiology)
• Reagent Strips (standards)
• Sensitivity and Specificity
• Urinalysis (methods)