Abstract | INTRODUCTION:
Thiazolidinediones are increasingly used drugs for the treatment of Type 2 diabetes. The individual response to thiazolidinedione therapy, ranging from the variable degree of metabolic improvement to harmful side-effects, is empirical, yet the underlying mechanisms remain elusive. In order to assess the pharmacogenomic component of thiazolidinediones' metabolic action, we compared the effect of rosiglitazone in two genetically defined models of metabolic syndrome, polydactylous (PD) and BN.SHR4 inbred rat strains, with their insulin-sensitive, normolipidemic counterpart, the Brown Norway (BN) rat. MATERIALS & METHODS: 5-month-old male rats were fed a high-fat diet for 4 weeks, and the experimental groups received rosiglitazone (0.4 mg/100 g body weight) during the last 2 weeks of high-fat diet feeding. We assessed metabolic and morphometric profiles, oxidative stress parameters and gene expression in white adipose tissue. RESULTS: CONCLUSION:
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Authors | Ondrej Seda, Lucie Sedová, Olena Oliyarnyk, Ludmila Kazdová, Drahomíra Krenová, Gilles Corbeil, Pavel Hamet, Johanne Tremblay, Vladimír Kren |
Journal | Pharmacogenomics
(Pharmacogenomics)
Vol. 9
Issue 2
Pg. 141-55
(Feb 2008)
ISSN: 1462-2416 [Print] England |
PMID | 18370844
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, Dietary
- Dietary Carbohydrates
- Fatty Acids
- Hypoglycemic Agents
- Lipids
- Thiazolidinediones
- Rosiglitazone
- Sucrose
- RNA
- Glycogen
- Glucose
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Topics |
- Adipose Tissue
(drug effects, metabolism)
- Adipose Tissue, White
(drug effects, metabolism)
- Animals
- Cholesterol, Dietary
(pharmacology)
- Diet
- Dietary Carbohydrates
(pharmacology)
- Fatty Acids
(pharmacology)
- Gene Expression
(drug effects)
- Glucose
(metabolism)
- Glucose Tolerance Test
- Glycogen
(biosynthesis)
- Hypoglycemic Agents
(pharmacology)
- Insulin Resistance
- Lipids
(biosynthesis)
- Liver
(drug effects, metabolism)
- Metabolic Syndrome
(genetics, metabolism)
- Microarray Analysis
- Oxidation-Reduction
- Oxidative Stress
(drug effects)
- RNA
(biosynthesis, isolation & purification)
- Rats
- Rats, Inbred BN
- Rats, Inbred Strains
- Rosiglitazone
- Sucrose
(pharmacology)
- Thiazolidinediones
(pharmacology)
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