Abstract | PURPOSE: This review provides a brief update on genetic studies of primary hypercalciuria. We consider their possible implications for the pathogenesis and complications of primary hypercalciuria. MATERIALS AND METHODS: Using the PubMed, MEDLINE and Scopus databases we reviewed the literature on pathogenesis and the complications of hypercalciuria, giving particular attention to genetic studies in humans. RESULTS: CONCLUSIONS: The classic distinction among absorptive, renal and resorptive hypercalciuria seems insufficient to explain the many cellular and tissue modifications observed in patients with primary hypercalciuria. The condition seems to be a separate disorder, characterized by altered calcium transport in the intestine, kidney and bone, and caused by various combinations of multiple genetic and dietary changes.
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Authors | Giuseppe Vezzoli, Laura Soldati, Giovanni Gambaro |
Journal | The Journal of urology
(J Urol)
Vol. 179
Issue 5
Pg. 1676-82
(May 2008)
ISSN: 1527-3792 [Electronic] United States |
PMID | 18343451
(Publication Type: Journal Article, Review)
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Chemical References |
- Receptors, Calcium-Sensing
- Vitamin D
- Adenylyl Cyclases
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Topics |
- Adenylyl Cyclases
(genetics, metabolism)
- Genetic Linkage
- Humans
- Hypercalciuria
(complications, genetics, metabolism)
- Kidney Calculi
(urine)
- Osteoporosis
(urine)
- Receptors, Calcium-Sensing
(genetics, metabolism)
- Vitamin D
(genetics, metabolism)
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