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Calcium-Sensing Receptors

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A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.

Also Known As:

Receptors, Calcium-Sensing; CASR Protein; Ca-Sensing Receptors; Ca2+-Sensing Receptor; Calcium Receptors; Calcium-Sensing Receptor Protein; Extracellular Calcium-Ion Sensing Receptor; Parathyroid Calcium-Sensing Receptor; Receptor, Ca-Sensing; Receptors, Calcium; Ca Sensing Receptors; Ca-Sensing Receptor; Ca2+ Sensing Receptor; Calcium Sensing Receptor; Calcium Sensing Receptor Protein; Calcium Sensing Receptors; Calcium-Sensing Receptor, Parathyroid; Extracellular Calcium Ion Sensing Receptor; Parathyroid Calcium Sensing Receptor; Receptor Protein, Calcium-Sensing; Receptor, Ca Sensing; Receptor, Ca2+-Sensing; Receptor, Calcium-Sensing; Receptor, Parathyroid Calcium-Sensing; Receptors, Ca-Sensing; Receptors, Calcium Sensing; Calcium-Sensing Receptor

Networked: 340 relevant articles (2 outcomes, 18 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 58343
  - Membrane Proteins: 4073
    - Cell Surface Receptors: 547
      - G-Protein-Coupled Receptors: 441
        Calcium-Sensing Receptors: 340
        human CASR protein
        rat extracellular calcium cation-sensing receptor

Experts

1.	Brown, Edward M: 17 articles (12/2009 - 03/2002)
2.	Hendy, Geoffrey N: 13 articles (01/2009 - 03/2002)
3.	Brown, E M: 9 articles (09/2009 - 03/2000)
4.	Canaff, Lucie: 9 articles (01/2009 - 03/2002)
5.	Cole, David E C: 8 articles (01/2009 - 03/2002)
6.	Chattopadhyay, Naibedya: 7 articles (06/2009 - 12/2003)
7.	Chakrabarty, Subhas: 6 articles (02/2010 - 01/2003)
8.	Yano, Shozo: 6 articles (01/2010 - 12/2002)
9.	Thakker, Rajesh V: 5 articles (01/2010 - 01/2003)
10.	Tfelt-Hansen, Jacob: 5 articles (02/2008 - 12/2003)

Related Diseases

1.	Secondary Hyperparathyroidism 01/01/2010 - "Secondary hyperparathyroidism is partially due to decreased calcium-sensing receptor expression in parathyroid glands in these patients. " 02/01/2009 - "The identification of the calcium-sensing receptor (CaSR) involvement in the pathogenesis of primary and secondary hyperparathyroidism (SHPT) and the availability of a new class of drugs called calcimimetics are two outstanding examples. " 02/01/2005 - "The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism." 05/01/2003 - "In addition, calcimimetic agents may represent a new pharmacologic choice to the treatment of secondary hyperparathyroidism, binding parathyroid calcium sensing receptors (CaSR) and reducing PTH secretion. " 12/01/2002 - "Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function." Order ALL the reference details at left...
2.	Hyperplasia 07/01/2005 - "In uremic patients, severe parathyroid hyperplasia is associated with reduced parathyroid calcium-sensing receptor (CaR) expression. " 02/01/2005 - "Calcimimetic agents acting through allosteric modification of the calcium-sensing receptor (CaR) can attenuate parathyroid hyperplasia in rats with secondary HPT. " 11/01/2008 - "down-regulation of the calcium-sensing receptor, and the increase of the PT cell number in nodular hyperplasia are the main causes of refractory secondary hyperparathyroidism. " 11/01/2001 - "BACKGROUND: Recent evidence points to a relationship between the down-regulation of the calcium-sensing receptor (CaR) and parathyroid cell hyperplasia that is associated with chronic renal failure. " 03/01/2000 - "Calcium-sensing receptor expression and signalling in human parathyroid adenomas and primary hyperplasia." Order ALL the reference details at left...
3.	Hyperparathyroidism 01/01/1998 - "We conclude that the activation of parathyroid cell calcium receptors by a novel calcimimetic compound is safe and effective in acutely suppressing PTH secretion in dialysis patients with hyperparathyroidism. " 09/01/2007 - "INTRODUCTION: Neonatal severe hyperparathyroidism (NSHPT) is induced by inactivating mutations of human calcium-sensing receptor (CaSR). " 09/01/2007 - "Neonatal severe hyperparathyroidism associated with a novel de novo heterozygous R551K inactivating mutation and a heterozygous A986S polymorphism of the calcium-sensing receptor gene." 12/01/2006 - "Novel mutation of the calcium sensing receptor gene in familial hypocalciuric hypercalcaemia and neonatal severe hyperparathyroidism." 01/01/2006 - "Neonatal severe hyperparathyroidism (NSHPT) is a life-threatening disorder usually caused by homozygous mutations occurring in the calcium-sensing receptor (CaR) gene. " Order ALL the reference details at left...
4.	Hypercalcemia (Milk Alkali Syndrome) 12/01/2002 - "In this study, we report an 84-year-old female proband in a Japanese family with familial hypocalciuric hypercalcemia (FHH) caused by an R648stop mutation in the extracellular calcium-sensing receptor (CaR) gene. " 11/01/2009 - "A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia." 06/01/2009 - "Familial hypocalciuric hypercalcemia (FHH) is known to be caused by heterozygous inactivating mutations of the calcium sensing receptor (CaSR) gene. " 06/01/2009 - "Neonatal hypercalcemia due to polymorphisms of the calcium sensing receptor." 04/01/2009 - "Sequencing analysis of the calcium sensing receptor gene revealed a novel heterozygous mutation (3193delA) in the patient and his family members with hypercalcemia, but one with normocalcemia. " Order ALL the reference details at left...
5.	Neoplasms (Cancer) 06/01/2006 - "AIMS: This study investigates whether the calcium-sensing receptor (CaR) is commonly expressed in primary breast cancers. " 02/01/1998 - "STUDY DESIGN: Ovarian surface epithelial cells from normal patients and from ovarian tumors were tested for calcium-sensing receptor expression by Northern hybridization and immunoblot analysis. " 06/01/2009 - "Calcium-sensing receptor in cancer: good cop or bad cop?" 04/01/2009 - "The role of the calcium-sensing receptor in the development and progression of cancer." 09/01/2006 - "Roles for the calcium sensing receptor in primary and metastatic cancer." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Calcitriol Receptors (Calcitriol Receptor)
2.	maxacalcitol
3.	Calcium
4.	Parathyroid Hormone (Parathormone)
5.	cinacalcet (Sensipar)
6.	Vitamin D
7.	GTP-Binding Proteins (G-Protein)
8.	Serine Proteases (Serine Protease)
9.	Aquaporin 2
10.	beta Catenin

Related Therapies and Procedures

1.	Kidney Transplantation
2.	Renal Dialysis (Hemodialysis)
3.	Tocolysis
4.	Homologous Transplantation (Allograft)

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