Abstract | BACKGROUND: A high intake of magnesium, calcium, and potassium and a low intake of sodium have been hypothesized to reduce the risk of stroke. However, prospective data relating intake of these minerals to risk of stroke are inconsistent. METHODS: RESULTS: After adjustment for age and cardiovascular risk factors, a high magnesium intake was associated with a statistically significant lower risk of cerebral infarction but not with intracerebral or subarachnoid hemorrhages. The multivariate relative risk of cerebral infarction was 0.85 (95% confidence interval, 0.76-0.97; P for trend = .004) for men in the highest quintile of magnesium intake compared with those in the lowest quintile. The inverse association between magnesium intake and cerebral infarction was stronger in men younger than 60 years (relative risk, 0.76; 95% confidence interval, 0.64-0.89; P for interaction = .02). Calcium, potassium, and sodium intake was not significantly associated with risk of any subtype of stroke (P for trend > .05). CONCLUSION:
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Authors | Susanna C Larsson, Mikko J Virtanen, Monica Mars, Satu Männistö, Pirjo Pietinen, Demetrius Albanes, Jarmo Virtamo |
Journal | Archives of internal medicine
(Arch Intern Med)
Vol. 168
Issue 5
Pg. 459-65
(Mar 10 2008)
ISSN: 0003-9926 [Print] United States |
PMID | 18332289
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Sodium
- Magnesium
- Potassium
- Calcium
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Topics |
- Calcium
(administration & dosage)
- Cerebral Hemorrhage
(epidemiology)
- Diet
- Finland
(epidemiology)
- Humans
- Magnesium
(administration & dosage)
- Male
- Middle Aged
- Models, Statistical
- Potassium
(administration & dosage)
- Risk Factors
- Smoking
(adverse effects)
- Sodium
(administration & dosage)
- Stroke
(epidemiology, etiology, prevention & control)
- Surveys and Questionnaires
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