Detection of autoantibodies against NMDA-type glutamate receptor in a patient with recurrent optic neuritis and transient cerebral lesions.

Abstract

We describe the case of a Japanese girl with recurrent optic neuritis and transient cerebral lesions. Antibodies against N-methyl-d-aspartate (NMDA)-type glutamate receptors were detected in both serum and cerebrospinal fluid. Results of this case study suggest that the development of autoantibodies against NMDA-type glutamate receptors may play a role in the pathogenesis of central nervous system demyelinating diseases.

• Authors: N Ishikawa, G Tajima, S Hyodo, Y Takahashi, M Kobayashi
• Journal: Neuropediatrics (Neuropediatrics) Vol. 38 Issue 5 Pg. 257-60 (Oct 2007) ISSN: 0174-304X [Print] Germany
• PMID: 18330842 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• NR2B NMDA receptor
• Receptors, Glutamate
• Receptors, N-Methyl-D-Aspartate
• glutamate receptor delta 2

Topics

• Autoantibodies (blood)
• Child
• Diagnosis, Differential
• Dominance, Cerebral (physiology)
• Encephalomyelitis, Acute Disseminated (diagnosis, immunology)
• Epilepsy, Partial, Motor (diagnosis, immunology)
• Epilepsy, Tonic-Clonic (diagnosis, immunology)
• Female
• Follow-Up Studies
• Frontal Lobe (pathology)
• Humans
• Magnetic Resonance Imaging
• Multiple Sclerosis (diagnosis, immunology)
• Neuromyelitis Optica (diagnosis, immunology)
• Optic Nerve (pathology)
• Optic Neuritis (immunology)
• Parietal Lobe (pathology)
• Receptors, Glutamate (immunology)
• Receptors, N-Methyl-D-Aspartate (immunology)
• Recurrence