Abstract |
The aim of the study was to investigate the effects of two anaesthetic techniques (total intravenous technique vs. inhalational technique) on changes in pro- and anti-inflammatory cytokine levels during open cholecystectomy. Forty ASA PS I-II patients undergoing open cholecystectomy were randomly assigned to two groups. Group R received total intravenous anaesthesia with propofol and remifentanil and group F received balanced inhalational anaesthesia with isoflurane. The plasma levels of tumour necrosis factor-alpha ( TNF-alpha), interleukin IL-6 and interleukin IL-10 were measured during and after surgery. The pro-inflammatory cytokine levels (TNF-alpha and IL-6) and the anti-inflammatory cytokine (IL-10) showed a significant increase in their concentrations compared with pre-induction levels in both groups (P < 0.05). By the end of anaesthesia and surgery, TNF-alpha and IL-6 were significantly lower in group R than in group F (P < 0.05). At the end of anaesthesia and 12 hours postoperatively, IL-10 levels in group R were higher than in group F (P < 0.05). These findings suggest that total intravenous anaesthesia using propofol and remifentanil suppresses the inflammatory response caused by surgery to a greater extent than a balanced inhalation technique using isoflurane.
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Authors | J J Ke, J Zhan, X B Feng, Y Wu, Y Rao, Y L Wang |
Journal | Anaesthesia and intensive care
(Anaesth Intensive Care)
Vol. 36
Issue 1
Pg. 74-8
(Jan 2008)
ISSN: 0310-057X [Print] United States |
PMID | 18326136
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Inhalation
- Anesthetics, Intravenous
- Cytokines
- Interleukin-6
- Piperidines
- Tumor Necrosis Factor-alpha
- Interleukin-10
- Isoflurane
- Remifentanil
- Propofol
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Topics |
- Anesthesia
(methods)
- Anesthesia, Inhalation
(methods)
- Anesthesia, Intravenous
(methods)
- Anesthetics, Inhalation
(pharmacology)
- Anesthetics, Intravenous
(pharmacology)
- Cholecystectomy
- Cytokines
(blood, drug effects)
- Female
- Humans
- Interleukin-10
(blood)
- Interleukin-6
(blood)
- Isoflurane
(pharmacology)
- Male
- Middle Aged
- Piperidines
(pharmacology)
- Propofol
(pharmacology)
- Remifentanil
- Time Factors
- Tumor Necrosis Factor-alpha
(blood, drug effects)
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