Abstract | BACKGROUND: HYPOTHESIS: ANIMALS: METHODS: Placebo-controlled, double-blind clinical trial. Cats were randomly entered into 1 of 2 treatment groups: treated PO with either 5 mg/kg pradofloxacin q24h or 5 mg/kg doxycycline q12h for 42 consecutive days. Changes in health status and clinical scores were evaluated. The presence of C. felis and Mycoplasma spp. was determined by quantitative polymerase chain reaction (PCR) and nested PCR of conjunctival swabs, respectively. RESULTS: At the beginning of the study, C. felis and Mycoplasma spp. were detected in 23 and 20 cats, respectively. Cats of both groups responded rapidly with a marked improvement in clinical signs within the 1st week. During treatment with either drug, C. felis DNA copy number declined quickly. Complete elimination of Mycoplasma spp. was achieved in both groups; however, whereas all cats receiving doxycycline eliminated C. felis, 4 cats treated with pradofloxacin remained PCR-positive. CONCLUSION AND CLINICAL IMPORTANCE:
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Authors | A D Hartmann, C R Helps, M R Lappin, C Werckenthin, K Hartmann |
Journal | Journal of veterinary internal medicine
(J Vet Intern Med)
2008 Jan-Feb
Vol. 22
Issue 1
Pg. 44-52
ISSN: 0891-6640 [Print] United States |
PMID | 18289288
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Fluoroquinolones
- pradofloxacin
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Topics |
- Animals
- Anti-Bacterial Agents
(therapeutic use)
- Cat Diseases
(drug therapy)
- Cats
- Chlamydophila Infections
(drug therapy, microbiology, veterinary)
- Double-Blind Method
- Fluoroquinolones
(therapeutic use)
- Mycoplasma Infections
(drug therapy, microbiology, veterinary)
- Respiratory Tract Infections
(drug therapy, microbiology, veterinary)
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