Bacopa monniera exerts antiamnesic effect on diazepam-induced anterograde amnesia in mice.

Abstract

RATIONALE:

As Benzodiazepines are known to produce amnesia by involvement of the GABAergic system, we examined Bacopa monniera, an herb known for memory enhancement for reversal of memory deficits caused by diazepam.

OBJECTIVES:

The objective of the study was to study the effect of standardized extract of B. monniera on diazepam-induced amnesia in mice using Morris water maze.

MATERIALS AND METHODS:

We used the rota rod test as a screening measure for muscle incoordination followed by the Morris water maze scale to evaluate the effect of B. monniera on amnesia. The index of acquisition and retrieval was recorded with varying doses of Bacopa.

RESULTS:

The results revealed antiamnesic effects of B. monniera (120 mg kg(-1) oral) on diazepam (1.75 mg kg(-1) intraperitoneal)-induced amnesia. The degree of reversal by Bacopa was significant as it progressively reduced escape latency time when mice treated with diazepam were subjected to acquisition trials.

CONCLUSIONS:

The antiamnesic effects of Bacopa suggest likely a gamma-aminobutyric acid-benzodiazepine pathway possibly affecting long-term potentiation.

• Authors: Sudesh Prabhakar, Manish Kumar Saraf, Promila Pandhi, Akshay Anand
• Journal: Psychopharmacology (Psychopharmacology (Berl)) Vol. 200 Issue 1 Pg. 27-37 (Sep 2008) ISSN: 0033-3158 [Print] Germany
• PMID: 18193203 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Anxiety Agents
• Plant Extracts
• Receptors, GABA-A
• Diazepam

Topics

• Amnesia, Anterograde (chemically induced, drug therapy)
• Animals
• Anti-Anxiety Agents (toxicity)
• Bacopa (chemistry)
• Diazepam (toxicity)
• Dose-Response Relationship, Drug
• Male
• Maze Learning (drug effects)
• Mice
• Plant Extracts (administration & dosage, pharmacology)
• Psychomotor Performance (drug effects)
• Receptors, GABA-A (drug effects, metabolism)