Clinical benefit of a short term dietary oatmeal intervention in patients with type 2 diabetes and severe insulin resistance: a pilot study.

Abstract

AIMS/HYPOTHESIS:

To evaluate the potential effectiveness of 'carbohydrate days' as a dietary intervention to overcome insulin resistance in type 2 diabetes.

MATERIALS AND METHODS:

Patients (n=14) with uncontrolled type 2 diabetes and insulin resistance as defined by a dosage of more than 1 IU/day (*)kg BW were consecutively enrolled in this prospective study. Primary outcomes were daily insulin requirement and mean blood glucose levels which were evaluated before, after, and 4 weeks after the intervention.

RESULTS:

All patients had a metabolic syndrome, 75% had microvascular and 57.1% macrovascular complications. Hospital setting and diabetes adapted diet alone led to improved glycemic control with a mean blood glucose 158+/-47 mg/dl. Intervention with two days of oatmeal diet further decreased mean blood glucose to 118+/-37 mg/dl (p<0.05). This was associated with a significant reduction of insulin dosage by 42.5% (before: 145+/-68.9 U/d, after 83+/-34.2 U/d, p<0.001) as well as a significant reduction (-26.4%, p<0.01) of serum leptin levels. After the four weeks outpatient period, insulin dosage remained significantly decreased (83+/-20.2 U/kg (*)d, p<0.01). Glycemic control was comparable (mean blood glucose141+/-20.78 mg/dl) to glucose levels within the hospital setting. Adiponectin levels increased significantly by 53.8% (p<0.05).

CONCLUSIONS:

In this uncontrolled pilot study, hospital admission and diabetes adapted diet followed by oatmeal intervention achieved a approximately 40% reduction of insulin dosage required to achieve controlled glucose levels. This effect was conserved after a 4 week outpatient phase with normal diet.

• Authors: A Lammert, J Kratzsch, J Selhorst, P M Humpert, A Bierhaus, R Birck, K Kusterer, H-P Hammes
• Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association (Exp Clin Endocrinol Diabetes) Vol. 116 Issue 2 Pg. 132-4 (Feb 2008) ISSN: 0947-7349 [Print] Germany
• PMID: 18095234 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• ADIPOQ protein, human
• Adiponectin
• Glycated Hemoglobin A
• Insulin
• Lipids
• hemoglobin A1c protein, human

Topics

• Adiponectin (blood)
• Avena
• Combined Modality Therapy
• Diabetes Mellitus, Type 2 (blood, complications, diet therapy, drug therapy)
• Dose-Response Relationship, Drug
• Glycated Hemoglobin (analysis)
• Humans
• Insulin (administration & dosage)
• Insulin Resistance
• Lipids (blood)
• Metabolic Syndrome (blood, complications, diet therapy, drug therapy)
• Pilot Projects
• Time Factors
• Treatment Outcome