[Effects of melittin on growth and angiogenesis of human hepatocellular carcinoma BEL-7402 cell xenografts in nude mice].
Abstract | BACKGROUND & OBJECTIVE: METHODS: RESULTS: The relative tumor volume (V/V0) and MVD were significantly lower in low, moderate and high dose melittin groups than in NS group (4.42+/-0.58, 3.47+/-0.97, and 3.06+/-1.23 vs. 9.06+/-1.45, P<0.01; 11.33+/-1.86, 9.17+/-1.17, and 6.67+/-1.21 vs. 16.50+/-2.35, P<0.01). Tumor tissue necrosis was observed in melittin-treated groups and tumor vessels were destroyed by melittin. The positive expression indexes of VEGF (2.59+/-0.27, 2.61+/-0.17, 1.55+/-0.22 vs. 3.80+/-0.60, P<0.01), bFGF (2.45+/-0.78, 2.27+/-0.36, 2.10+/-0.27 vs. 4.43+/-0.34, P<0.01) and NF-kappaB (2.79+/-0.29, 2.71+/-0.66, 2.26+/-0.56 vs. 4.98+/-0.63, P<0.01) were significantly lower in low, moderate and high dose melittin groups than in NS group. The mRNA levels of VEGF and bFGF were also significantly lower in melittin-treated groups than in NS group. CONCLUSIONS:
Melittin could inhibit the growth of BEL-7402 cell xenografts in nude mice. The down-regulation of VEGF, b-FGF and NF-kappaB expression and the inhibition of angiogenesis might play key roles in the antitumor effect of melittin.
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Authors | Chang-Cheng Song, Xiang Lu, Bin-Bin Cheng, Juan DU, Bai Li, Chang-Quan Ling |
Journal | Ai zheng = Aizheng = Chinese journal of cancer
(Ai Zheng)
Vol. 26
Issue 12
Pg. 1315-22
(Dec 2007)
China |
PMID | 18076793
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- NF-kappa B
- RNA, Messenger
- Vascular Endothelial Growth Factor A
- Fibroblast Growth Factor 2
- Melitten
|
Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Carcinoma, Hepatocellular
(metabolism, pathology)
- Cell Line, Tumor
- Down-Regulation
- Fibroblast Growth Factor 2
(genetics, metabolism)
- Humans
- Liver Neoplasms
(metabolism, pathology)
- Male
- Melitten
(pharmacology)
- Mice
- Mice, Inbred BALB C
- Mice, Nude
- Microvessels
(drug effects)
- NF-kappa B
(metabolism)
- Neoplasm Transplantation
- Neovascularization, Pathologic
(pathology)
- RNA, Messenger
(metabolism)
- Random Allocation
- Tumor Burden
(drug effects)
- Vascular Endothelial Growth Factor A
(genetics, metabolism)
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