Vaccination with IL-6 analogues induces autoantibodies to IL-6 and influences experimentally induced inflammation.
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| Abstract |
IL-6 is involved in inflammation and a therapeutic target. 0.1% of Danish blood donors have nanomolar plasma concentrations of polyclonal, picomolar affinity and in vitro as well as in vivo neutralizing IgG autoantibodies to IL-6 (aAb-IL-6). Such donors are assumed to be severely IL-6 deficient; yet they appear healthy and do not exhibit overt clinical or laboratory abnormalities. We induced comparable levels of aAb-IL-6 in different mouse strains by vaccination with immunogenic IL-6 analogues. We observed that the induced aAb-IL-6 protected against collagen-induced arthritis and experimental allergic encephalitis. Furthermore, aAb-IL-6 carrying mice displayed increased plasma TNFalpha concentrations upon challenge with LPS. Taken together, induction of IL-6 autoantibodies was possible in different mouse strains. The autoantibodies influenced experimental inflammation. This immunotherapeutic principle might be a viable alternative in immune competent humans suffering from disorders driven by IL-6.
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| Authors | Pia Galle, Lene Jensen, Christina Andersson, Salvatore Cuzzocrea, Rosanna Di Paola, Ferdinando Nicoletti, Morten Svenson, Klaus Bendtzen, Allan R Thomsen, Morten B Hansen |
| Journal | International immunopharmacology (Int Immunopharmacol) Vol. 7 Issue 13 Pg. 1704-13 (Dec 15 2007) ISSN: 1567-5769 [Print] Netherlands |
| PMID | 17996680 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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