[Clinical analysis of juvenile ovary granulose cell tumor].

Abstract

OBJECTIVE:

To explore clinicopathological features and prognosis of juvenile granulosa cell tumor (JGCT).

METHODS:

Patients were divided into JGCT group (n = 10) and the adult granulosa cell tumor (AGCT) group (n = 10). The tumor samples were examined by HE and immunohistochemical methods.

RESULTS:

Age of JGCT group ranged from 7 - 31 years (average 20.5 years); 90% occurred before 30 years old. Diameter of the tumors ranged from 5.5 cm to 15.0 cm, average 9.8 cm. Characteristic features included nodular arrangement, irregular formation of follicles containing mucin and luteinization, atypical hyperplasia of cells and high mitotic activity. Nuclei grooved and Call-Exner bodies were absent or rare. Survival rate was 90% in 5 years. Age of AGCT group ranged from 14 - 74 years (average 45.1 years); AGCT occurred mostly in over 40 years old. Atypical hyperplasia of cell, mitotic activity and luteinization were absent or rare. Nuclei grooved and call-Exner bodies were common. Survival rate was 100% in 5 years. Immunohistochemical staining were positive for p53 at 70%, PCNA at 90% in 10 cases of JGCT and p53 at 10%, PCNA at 20% in 10 cases of AGCT (P < 0.05 between two groups).

CONCLUSIONS:

JGCT differs in clinicopathologic feature from the AGCT. It has higher mitotic activity and nuclear atypicality as well as the expression of PCNA and p53. Prognosis of JGCT is worse than AGCT.

• Authors: Jiang-ning Huang, Yi-zhi Liu, Xin-min Zhang
• Journal: Zhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 42 Issue 8 Pg. 533-6 (Aug 2007) ISSN: 0529-567X [Print] China
• PMID: 17983492 (Publication Type: English Abstract, Journal Article)

Chemical References

• Proliferating Cell Nuclear Antigen
• Tumor Suppressor Protein p53

Topics

• Adolescent
• Adult
• Aged
• Animals
• Child
• Diagnosis, Differential
• Female
• Follow-Up Studies
• Granulosa Cell Tumor (metabolism, mortality, pathology)
• Humans
• Immunohistochemistry
• Middle Aged
• Neoplasm Staging
• Ovarian Neoplasms (metabolism, mortality, pathology)
• Prognosis
• Proliferating Cell Nuclear Antigen (biosynthesis)
• Retrospective Studies
• Survival Analysis
• Survival Rate
• Tumor Suppressor Protein p53 (biosynthesis)