Abstract | AIMS: METHODS: Twenty six patients with type 1 diabetes (mean duration 32+/-5 years), and 16 age matched controls were recruited. Mean HbA(1c) through 18 years (HbA(1c)18), serum levels of AGEs and coronary atherosclerotic burden (CAB) were determined by IVUS. Peak tissue velocities and strain by tissue Doppler imaging were measured in 12 LV regions as an evaluation of LV function. RESULTS: Systolic tissue velocity was inversely correlated to CAB (r=0.53, p<0.01), to HbA(1c)18 (r=0.46, p<0.05) and to the duration of diabetes (r=0.46, p<0.05). Systolic strain was inversely correlated to HbA(1c)18 (r=0.45, p<0.05), to duration of diabetes (r=0.41, p<0.05), and tended to correlate with AGEs (r=0.37, p=0.07). In multiple regression analyses, CAB and HbA(1c)18 were significant independent predictors for systolic velocity, while AGEs and duration of diabetes were significant predictors of systolic strain. CONCLUSION:
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Authors | Kjetil Steine, Jakob R Larsen, Marie Stugaard, Tore Julsrud Berg, Magne Brekke, Knut Dahl-Jørgensen |
Journal | European journal of heart failure
(Eur J Heart Fail)
Vol. 9
Issue 10
Pg. 1044-50
(Oct 2007)
ISSN: 1388-9842 [Print] England |
PMID | 17719271
(Publication Type: Journal Article)
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Chemical References |
- Glycated Hemoglobin A
- Glycation End Products, Advanced
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Topics |
- Adult
- Case-Control Studies
- Coronary Artery Disease
(diagnostic imaging, physiopathology)
- Diabetes Mellitus, Type 1
(diagnostic imaging, physiopathology)
- Disease Progression
- Female
- Glycated Hemoglobin
- Glycation End Products, Advanced
- Heart Failure
(physiopathology)
- Heart Ventricles
(diagnostic imaging, pathology)
- Humans
- Hyperglycemia
(prevention & control)
- Male
- Middle Aged
- Risk Factors
- Time Factors
- Ultrasonography
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