Diagnostic value of homocysteine, C-reactive protein and bilirubin for coronary artery disease.

Abstract

We evaluated 3 new markers for coronary artery disease (CAD) [bilirubin, total homocysteine (t-Hcy) and high-sensitivity C-reactive protein (hs-CRP)] in 319 patients with chest pains divided into 2 groups based on coronary angiography: CAD group (n = 262) and non-CAD group (n = 57). A control group consisted of 50 healthy subjects. t-Hcy had the highest diagnostic value for diagnosis of angiographically documented patients; bilirubin had the lowest. The sensitivities and specificities (based on ROC curves) of bilirubin, hs-CRP and t-Hcy were 70.9%, 50% and 76.8% respectively, and 40.4%, 80.7% and 70.2% respectively. We conclude that serum bilirubin levels cannot identify people at risk of CAD and t-Hcy and hs-CRP may be stronger markers.

• Authors: N Yilmaz, H K Ciçek, A Celik, I Meram, R Kocabas, V Davutoglu
• Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit (East Mediterr Health J) 2007 May-Jun Vol. 13 Issue 3 Pg. 522-35 ISSN: 1020-3397 [Print] Egypt
• PMID: 17687824 (Publication Type: Journal Article, Validation Study)

Chemical References

• Biomarkers
• Homocysteine
• C-Reactive Protein
• Bilirubin

Topics

• Analysis of Variance
• Area Under Curve
• Bilirubin (blood)
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Case-Control Studies
• Chest Pain (etiology)
• Chi-Square Distribution
• Coronary Angiography
• Coronary Artery Disease (blood, complications, diagnosis)
• Female
• Homocysteine (blood)
• Humans
• Logistic Models
• Male
• Middle Aged
• ROC Curve
• Risk Factors
• Sensitivity and Specificity
• Statistics, Nonparametric
• Turkey