Abstract | CONTEXT: OBJECTIVE: DESIGN AND SETTING: The study is descriptive and took place at a university medical center. PATIENTS: Eight adult CAH patients with bilateral testicular adrenal rest tumors were treated with testis-sparing surgery. INTERVENTIONS: MAIN OUTCOME MEASURES: RESULTS: 21DF, 17OHP, and A levels were measurable in all spermatic vein samples. The ratio (mean +/- SD) between spermatic vein and simultaneously taken peripheral blood samples was 37.8 +/- 56.3 (21DF), 132.0 +/- 249 (17OHP), and 57.0 +/- 68.2 (A). CYP11B1, CYP11B2, and ACTH and AII receptor mRNAs were detected in all tumors with a strong correlation between ACTH receptor mRNA in tumors and 21DF (r = 0.85; P = 0.015), 17OHP (r = 1; P = 0.01) and A (r = 0.89; P = 0.007) concentrations in peripheral blood. CONCLUSION: Testicular adrenal rest tumors produce adrenal-specific steroids and express adrenal-specific enzymes and ACTH and AII receptors, confirming the strong resemblance with adrenal tissue. Because AII receptors are present in tumor tissue, it can be hypothesized that AII may be an additional factor responsible for testicular adrenal rest tumor growth.
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Authors | Hedi L Claahsen-van der Grinten, Barto J Otten, Fred C G J Sweep, Paul N Span, H Alec Ross, Eric J H Meuleman, Ad R M M Hermus |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 92
Issue 9
Pg. 3674-80
(Sep 2007)
ISSN: 0021-972X [Print] United States |
PMID | 17595257
(Publication Type: Journal Article)
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Chemical References |
- RNA, Messenger
- Receptors, Angiotensin
- Receptors, Corticotropin
- Androstenedione
- 17-alpha-Hydroxyprogesterone
- Steroid 21-Hydroxylase
- Cytochrome P-450 CYP11B2
- Steroid 11-beta-Hydroxylase
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Topics |
- 17-alpha-Hydroxyprogesterone
(blood)
- Adrenal Cortex
(metabolism, physiopathology)
- Adrenal Hyperplasia, Congenital
(complications, genetics, metabolism, physiopathology)
- Adrenal Rest Tumor
(etiology, genetics, metabolism, physiopathology)
- Adult
- Androstenedione
(blood)
- Cytochrome P-450 CYP11B2
(blood, genetics, metabolism)
- Humans
- Male
- Middle Aged
- RNA, Messenger
(analysis, metabolism)
- Receptors, Angiotensin
(genetics, metabolism)
- Receptors, Corticotropin
(genetics, metabolism)
- Steroid 11-beta-Hydroxylase
(blood, genetics, metabolism)
- Steroid 21-Hydroxylase
(blood, genetics)
- Testicular Neoplasms
(etiology, genetics, metabolism, physiopathology)
- Testis
(blood supply)
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