Abstract | BACKGROUND: METHODS AND RESULTS: 95 patients with metabolic syndrome (56 M/39 F) and 195 healthy persons (99 M/96 F) were included into the cohort. Basic clinical data, parameters of glucose homeostasis, lipid concentration in plasma and conjugated diens in LDL were determined. Fatty acids were detected by capillary gas chromatography. Polymorphisms of apolipoprotein E, intestinal isoforms of fatty acid binding protein (Ala54Thr) and y-2 isoforms of peroxisomal activated receptor (Alal2Pro) were analyzed using combination of polymerase chain reaction methods and by the detection of polymorphisms of the restriction fragment length. Persons with metabolic syndrome had higher concentrations of CRP and conjugated diens in LDL. In all lipid classes we proved a decreased concentration of n-6 polyunsaturated fatty acids and an increase of unsaturated fatty acids. From all the acids, the only significant was the decrease of linolic acid concentration and the increase of palmitic and palmitoyl acids. Results showed an increase of delta 9 palmitic acid desaturase activity, delta 6 linolic acid desaturase and elongase activity. Concentration of conjugated diens in LDL inversely correlated with linolic acid. Clinical or laboratory parameters and homozygotic combination of polymorphism studied were not mutually related. CONCLUSIONS: Changes in the profile of fatty acids during the metabolic syndrome results from the elevated lipogenesis and from the higher level of oxidative stress.
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Authors | A Zák, M Vecka, E Tvrzická, M Jáchymová, M Dusejovská, L Janíková, B Stanková, L Vávrová, J Kodydková, M Zeman |
Journal | Casopis lekaru ceskych
(Cas Lek Cesk)
Vol. 146
Issue 5
Pg. 484-91
( 2007)
ISSN: 0008-7335 [Print] Czech Republic |
Vernacular Title | Slození esterifikovaných mastných kyselin a lipoperoxidace u metabolického syndromu. |
PMID | 17554973
(Publication Type: Journal Article)
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Chemical References |
- Fatty Acids, Nonesterified
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Topics |
- Adult
- Fatty Acids, Nonesterified
(analysis)
- Female
- Humans
- Lipid Peroxidation
- Male
- Metabolic Syndrome
(blood, genetics, metabolism)
- Middle Aged
- Oxidative Stress
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