Abstract | OBJECTIVE: DESIGN AND SETTING: Prospective, randomized, controlled animal study in an investigational ICU at a university hospital. INTERVENTIONS: Eighteen female Merino sheep were prepared for chronic study and subjected to smoke inhalation and septic challenge according to an established protocol. MEASUREMENTS AND RESULTS: Whereas global hemodynamics and oxygenation remained stable in sham animals (no injury, no treatment), the injury contributed to a hypotensive-hyperdynamic circulation in the control group ( smoke inhalation and sepsis, no treatment), as indicated by a significant increase in cardiac index) and heart rate and a drop in mean arterial pressure. Treatment with ceftazidime ( smoke inhalation and sepsis, treatment group) stabilized cardiac index and heart rate and attenuated the decrease in mean arterial pressure. The deterioration in PaO2/FiO2 ratio and pulmonary shunt fraction (Qs/Qt) was significantly delayed and blunted by ceftazidime. At 24 h after injury a significant increase in airway obstruction scores of bronchi and bronchioles in both injured groups was observed. Ceftazidime significantly reduced airway obstruction vs. control animals. Whereas plasma nitrate/ nitrite levels increased similarly in the two injured groups, lung 3- nitrotyrosine content remained at the baseline level in the ceftazidime group. CONCLUSIONS:
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Authors | Marc O Maybauer, Dirk M Maybauer, John F Fraser, Lillian D Traber, Martin Westphal, Robert A Cox, Ruksana Huda, Yoshimitsu Y Nakano, Perenlei Enkhbaatar, Hal K Hawkins, David N Herndon, Daniel L Traber |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 33
Issue 7
Pg. 1219-1227
(Jul 2007)
ISSN: 0342-4642 [Print] United States |
PMID | 17503018
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Nitrates
- Nitrites
- 3-nitrotyrosine
- Tyrosine
- Ceftazidime
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Topics |
- Animals
- Anti-Bacterial Agents
(pharmacology)
- Blood Pressure
(drug effects)
- Ceftazidime
(pharmacology)
- Disease Models, Animal
- Female
- Heart Rate
(drug effects)
- Hemodynamics
(drug effects)
- Lung
(chemistry)
- Nitrates
(blood)
- Nitrites
(blood)
- Oxygen Consumption
(drug effects)
- Random Allocation
- Sheep
- Shock, Septic
(physiopathology)
- Smoke Inhalation Injury
(physiopathology)
- Tyrosine
(analogs & derivatives, analysis)
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