Abstract | BACKGROUND & AIMS: METHODS: RESULTS: ADRP ASO specifically decreased ADRP mRNA and protein levels in the livers of Lep(ob/ob) and DIO mice, without altering the levels of other lipid droplet proteins, that is, S3-12 and TIP47. ADRP ASO suppressed expression of lipogenic genes, reduced liver triglyceride content without affecting cholesterol, attenuated triglyceride secretion, and decreased serum triglyceride and alanine aminotransaminase levels. The reduction in hepatic steatosis by ADRP ASO was associated with improvement in glucose homeostasis in both Lep(ob/ob) and DIO mice. CONCLUSIONS:
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Authors | Yumi Imai, Gladys M Varela, Malaka B Jackson, Mark J Graham, Rosanne M Crooke, Rexford S Ahima |
Journal | Gastroenterology
(Gastroenterology)
Vol. 132
Issue 5
Pg. 1947-54
(May 2007)
ISSN: 0016-5085 [Print] United States |
PMID | 17484887
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Membrane Proteins
- Oligoribonucleotides, Antisense
- Perilipin-2
- Plin2 protein, mouse
- RNA, Messenger
- Alanine Transaminase
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Topics |
- Alanine Transaminase
(blood)
- Animals
- Fatty Liver
(metabolism, prevention & control)
- Female
- Gene Expression Regulation
(drug effects)
- Hypertriglyceridemia
(metabolism, prevention & control)
- Insulin Resistance
(physiology)
- Lipid Metabolism
(drug effects, physiology)
- Liver
(metabolism, pathology)
- Membrane Proteins
(genetics, metabolism)
- Mice
- Mice, Inbred C57BL
- Obesity
(metabolism, pathology)
- Oligoribonucleotides, Antisense
(pharmacology)
- Perilipin-2
- RNA, Messenger
(genetics, metabolism)
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