Abstract | PURPOSE: MATERIALS AND METHODS: 23 Otsuka- Long-Evans-Tokushima-Fatty (OLETF) rats and eight control Long-Evans-Tokushima-Otsuka (LETO) rats were divided into the following four groups: LETO group, control OLETF group, pioglitazone treated group (10mg/ kg/day), and rosiglitazone treated group (3mg/kg/day). RESULTS: A progressive increase in urinary protein excretion was observed in the diabetic rats. Glomerular VEGF expression in the control OLETF rats was significantly higher than in the control LETO rats. However, there was a significant reduction in both the glomerular VEGF expression and the VEGF mRNA levels after treatment with pioglitazone and rosiglitazone. The twenty-four hour urine protein levels were significantly decreased in both groups of the treated OLETF rats. CONCLUSION:
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Authors | Mi Young Lee, Eun Young Lee, Byung Jun Lee, Chan Sik Won, Jang Hyun Koh, Jang Yel Shin, Young Goo Shin, Byung Pil Cho, Choon Hee Chung |
Journal | Yonsei medical journal
(Yonsei Med J)
Vol. 48
Issue 2
Pg. 301-7
(Apr 30 2007)
ISSN: 0513-5796 [Print] Korea (South) |
PMID | 17461531
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hypoglycemic Agents
- Thiazolidinediones
- Vascular Endothelial Growth Factor A
- Rosiglitazone
- Pioglitazone
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Topics |
- Animals
- Diabetes Mellitus, Type 2
(drug therapy)
- Diabetic Nephropathies
(drug therapy)
- Disease Models, Animal
- Hypoglycemic Agents
(therapeutic use)
- Male
- Pioglitazone
- Rats
- Rats, Long-Evans
- Rosiglitazone
- Thiazolidinediones
(therapeutic use)
- Vascular Endothelial Growth Factor A
(genetics)
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