Abstract | BACKGROUND:
Propranolol, a nonselective beta1-2 antagonist, attenuates hypermetabolism and catabolism in severely burned patients. However, recent data suggest that propranolol impairs immune function and enhances inflammation. The purpose of the present study was to determine the effect of propranolol administration on infection, sepsis, and inflammation in severely burned pediatric patients. PATIENTS: A prospective, intent-to-treat study was performed; patient demographics (age, gender, burn size, and mortality); infectious episodes (colony count greater then 10); and sepsis (guidelines by the society of critical care medicine) were determined. Hypermetabolic response was determined by resting energy expenditure (REE), and the inflammatory response was determined by measuring serum cytokine expression. RESULTS: CONCLUSION:
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Authors | Marc G Jeschke, William B Norbury, Celeste C Finnerty, Ludwik K Branski, David N Herndon |
Journal | The Journal of trauma
(J Trauma)
Vol. 62
Issue 3
Pg. 676-81
(Mar 2007)
ISSN: 0022-5282 [Print] United States |
PMID | 17414346
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-Antagonists
- Anabolic Agents
- Inflammation Mediators
- Propranolol
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Topics |
- Adrenergic beta-Antagonists
(adverse effects, therapeutic use)
- Anabolic Agents
(adverse effects, therapeutic use)
- Burns
(drug therapy, immunology, metabolism)
- Child
- Energy Metabolism
- Female
- Humans
- Inflammation Mediators
(blood)
- Male
- Propranolol
(adverse effects, therapeutic use)
- Sepsis
(immunology)
- Systemic Inflammatory Response Syndrome
(etiology, immunology)
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