Abstract | AIM: RESEARCH DESIGN AND METHODS: Plasma BNP levels and LV geometry and diastolic filling indices, including the ratio of peak early transmitral Doppler flow (E) over flow propagation velocity (Vp) measured by colour M-mode Doppler echocardiography, were analysed in 98 consecutive asymptomatic patients with type 2 diabetes mellitus and 51 age-matched controls. RESULTS: The LV mass index and relative wall thickness were higher in diabetic groups than controls without any differences in LV systolic function. The frequency of diastolic dysfunction defined as E/Vp > or = 1.5 were 31% in diabetic groups and 15% in controls (chi(2) = 4.364, p = 0.037). By receiver-operating characteristic (ROC) curve analysis, a BNP cutoff value of 19.2 pg/ml in controls had a 53.1% positive predictive value (53.1%) and a high negative predictive value (94.4%) for E/Vp >/= 1.5, whereas a BNP cutoff value of 18.1 pg/ml in diabetic groups had a 61.8% positive and 97.3% negative predictive values. CONCLUSIONS:
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Authors | M Shimabukuro, N Higa, Y Oshiro, T Asahi, N Takasu |
Journal | Diabetes, obesity & metabolism
(Diabetes Obes Metab)
Vol. 9
Issue 3
Pg. 323-9
(May 2007)
ISSN: 1462-8902 [Print] England |
PMID | 17391158
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Natriuretic Peptide, Brain
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Topics |
- Biomarkers
(blood)
- Blood Pressure
(physiology)
- Diabetes Mellitus, Type 2
(complications, diagnostic imaging, physiopathology)
- Echocardiography, Doppler, Color
(methods)
- Female
- Heart Ventricles
(diagnostic imaging, pathology, physiopathology)
- Humans
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Predictive Value of Tests
- ROC Curve
- Ventricular Dysfunction, Left
(complications, diagnosis, diagnostic imaging)
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