Elevated C-reactive protein in acute coronary syndrome presentation is an independent predictor of long-term mortality and heart failure.

Abstract

OBJECTIVES:

To assess the ability of C-reactive protein (CRP) to predict long-term outcomes in a chest pain population.

DESIGN AND METHODS:

CRP was measured at presentation in 446 emergency department patients with acute coronary syndromes. All-cause mortality and hospital discharges for acute myocardial infarction (AMI) and congestive heart failure (CHF) were obtained for up to 8 years following the event.

RESULTS:

Kaplan-Meier analyses indicated that patients with CRP concentrations above the American Heart Association scientific statement cut-off had a higher rate for death and CHF admissions. After adjusting for troponin concentrations, in a Cox proportional hazard model, only CRP concentrations indicative of an acute phase response (i.e., >7.44 mg/L) were associated with a significant risk for death after 5 years and CHF readmission after 2 years.

CONCLUSIONS:

Patients presenting early with chest pain with elevated CRP concentrations have a greater long-term risk for death and heart failure.

• Authors: Peter A Kavsak, Andrew R MacRae, Alice M Newman, Viliam Lustig, Glenn E Palomaki, Dennis T Ko, Jack V Tu, Allan S Jaffe
• Journal: Clinical biochemistry (Clin Biochem) Vol. 40 Issue 5-6 Pg. 326-9 (Mar 2007) ISSN: 0009-9120 [Print] United States
• PMID: 17292342 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• C-Reactive Protein

Topics

• Aged
• Biomarkers (blood)
• C-Reactive Protein (metabolism)
• Female
• Heart Failure (blood, metabolism, mortality)
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Myocardial Infarction (blood, metabolism, mortality)
• Proportional Hazards Models
• Survival Rate