Abstract | PURPOSE: METHODS: We conducted a retrospective cohort study of 5167 members of Group Health, a health maintenance organization (HMO) in western Washington State, who were aged 18 years and older and who were on stable long-term warfarin therapy between 1 January 1992 and 31 December 2003. We made within-person comparisons between mean INR values in the 28 days after receipt of influenza, pneumococcal, tetanus, or hepatitis A vaccine versus mean INR values during other times. RESULTS: Receipt of influenza vaccine was not associated with a change in INR value (mean change, 0.01; 95% confidence interval (CI) -0.01 to 0.03); similar results were observed for pneumococcal (mean change 0.01; 95%CI -0.07 to 0.09), tetanus (mean change 0.03; 95%CI -0.03 to 0.10), and hepatitis A vaccines (mean change 0.03; 95%CI -0.10 to 0.14). CONCLUSIONS: Our results do not suggest that vaccinations lead to clinically significant alterations in coagulation measures among adults on chronic warfarin therapy.
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Authors | Michael L Jackson, Jennifer C Nelson, Robert T Chen, Robert L Davis, Lisa A Jackson, Vaccine Safety Datalink investigators |
Journal | Pharmacoepidemiology and drug safety
(Pharmacoepidemiol Drug Saf)
Vol. 16
Issue 7
Pg. 790-6
(Jul 2007)
ISSN: 1053-8569 [Print] England |
PMID | 17286320
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anticoagulants
- Hepatitis A Vaccines
- Influenza Vaccines
- Pneumococcal Vaccines
- Tetanus Toxoid
- Warfarin
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anticoagulants
(pharmacology)
- Blood Coagulation
(drug effects)
- Cohort Studies
- Drug Interactions
- Female
- Health Maintenance Organizations
- Hepatitis A Vaccines
(pharmacology)
- Humans
- Influenza Vaccines
(pharmacology)
- International Normalized Ratio
- Longitudinal Studies
- Male
- Middle Aged
- Pneumococcal Vaccines
(pharmacology)
- Retrospective Studies
- Tetanus Toxoid
(pharmacology)
- Warfarin
(pharmacology)
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