Abstract | PURPOSE OF REVIEW: To summarize recent findings that docosahexaenoate (DHA) is the precursor of stereospecific derivatives with anti-inflammatory and cytoprotective properties. RECENT FINDINGS: SUMMARY: Here, we summarize recent studies demonstrating that in brain ischemia-reperfusion and in retinal pigment epithelial cells exposed to oxidative stress stereospecific docosahexaenoate-oxygenation pathways are activated and lead to the formation of docosanoid messengers. Two docosahexaenoate-oxygenation pathways were identified: the first is responsible for the formation of the messenger neuroprotectin D1 and the second pathway, which is active in the presence of aspirin, leads to the formation of the resolvin-type mediators (17R-DHA). Neuroprotectin D1 induces antiapoptotic, anti-inflammatory signaling and is neuroprotective.
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Authors | Nicolas G Bazan |
Journal | Current opinion in clinical nutrition and metabolic care
(Curr Opin Clin Nutr Metab Care)
Vol. 10
Issue 2
Pg. 136-41
(Mar 2007)
ISSN: 1363-1950 [Print] England |
PMID | 17285000
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
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Chemical References |
- Neuroprotective Agents
- protectin D1
- Docosahexaenoic Acids
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Topics |
- Brain
(metabolism, pathology)
- Docosahexaenoic Acids
(metabolism)
- Humans
- Neuroprotective Agents
(metabolism)
- Oxidative Stress
(drug effects, physiology)
- Reperfusion Injury
(metabolism, pathology)
- Retina
(metabolism, pathology)
- Signal Transduction
(physiology)
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