Clinical significance of MMP-2 and MMP-9 in patients with oral cancer.

Abstract

BACKGROUND:

Factors that represent the potential for invasion and metastasis, such as matrix metalloproteinases (MMPs), could predict prognosis of cancer. Therefore, the authors studied plasma and tissue levels of MMP-2 and MMP-9 in oral cancer, the leading malignancy in India.

METHODS:

Enzyme-linked immunosorbent assay and gelatin zymography were used for the MMP analysis from plasma and tissue samples, respectively.

RESULTS:

Latent, active, and total forms and activation ratio of MMP-2 and MMP-9 were significantly elevated in malignant tissues as compared with adjacent normal tissues. Activation of MMP-2 was higher than MMP-9 in malignant tissues. Activation ratio was significantly higher in malignant tissues of the patients with lymph node metastasis as compared with those without lymph node metastasis (p = .005). Plasma MMP-9 levels were significantly lower in responders as compared with pretreatment levels (p = .002).

CONCLUSION:

The data indicate that MMP-2 and MMP-9 can be useful to identify metastatic phenotype as well as for treatment monitoring in oral cancer.

• Authors: Beena P Patel, Shakuntala V Shah, Shilin N Shukla, Pankaj M Shah, Prabhudas S Patel
• Journal: Head & neck (Head Neck) Vol. 29 Issue 6 Pg. 564-72 (Jun 2007) ISSN: 1043-3074 [Print] United States
• PMID: 17252594 (Publication Type: Journal Article)
• Copyright: (c) 2007 Wiley Periodicals, Inc. Head Neck, 2007.

Chemical References

• Biomarkers, Tumor
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9

Topics

• Adult
• Aged
• Biomarkers, Tumor (metabolism)
• Carcinoma, Squamous Cell (metabolism, mortality, pathology, therapy)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Lymph Nodes (metabolism)
• Lymphatic Metastasis
• Male
• Matrix Metalloproteinase 2 (metabolism)
• Matrix Metalloproteinase 9 (metabolism)
• Middle Aged
• Mouth (metabolism, pathology)
• Mouth Neoplasms (metabolism, mortality, pathology, therapy)