Abstract | UNLABELLED: METHODS AND RESULTS: We studied 40 consecutive patients who underwent RF catheter ablation; 20 were men and 20 women and their age was 47 +/- 16 (16-77) years. All patients underwent electrophysiological study and subsequent RF ablation. Peripheral venous samples were collected before the procedure (baseline), immediately after the procedure, 2 h post-procedure and the following day (20 h post-procedure) and assayed for CK, the MB isoenzyme of CK, cardiac Tn-I and IMA. Ischaemia-modified albumin plasma levels did not differ significantly at all four time points, baseline, and following ablation (P = 0.5974), whereas CK, CK-MB, and Tn-I increased significantly at all time points compared with baseline (P < 0.0001). Post-ablation, all but three 3 CK measurements were in the normal range; 14 patients had CK-MB plasma levels above the upper limit of normal; all but one patient had Tn-I elevated. CONCLUSION: The IMA plasma levels do not change significantly following RF ablation, unlike biomarkers of myocardial injury, implying that myocardial necrosis occurs without preceding ischaemia.
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Authors | Eftihia Sbarouni, Panagiota Georgiadou, Demosthenes Panagiotakos, Efthimios G Livanis, George N Theodorakis, Dimitrios Th Kremastinos |
Journal | Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
(Europace)
Vol. 9
Issue 2
Pg. 127-9
(Feb 2007)
ISSN: 1099-5129 [Print] England |
PMID | 17213337
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Serum Albumin
- Troponin I
- Creatine Kinase, MB Form
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Topics |
- Adolescent
- Adult
- Aged
- Analysis of Variance
- Arrhythmias, Cardiac
(blood, surgery)
- Atrial Flutter
- Biomarkers
(blood)
- Catheter Ablation
- Creatine Kinase, MB Form
(blood)
- Female
- Humans
- Male
- Middle Aged
- Myocardial Ischemia
(blood)
- Serum Albumin
(analysis)
- Treatment Outcome
- Troponin I
(blood)
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