Abstract |
Leprechaunism was first recognized in 1954 and is characterized by severe intrauterine and postnatal growth retardation, failure to thrive, lipoatrophy, dysmorphic features (globular eyes, large ears, and micrognathia), hirsutism and acanthosis nigricans. The presented infant, a 30 day-old boy, had multiple phenotypic anomalies, including low-set ears, prominent eyes, decreased subcutaneous fat, hirsutism, breast hyperplasia, and penile enlargement. We found persistent hyperglycemia with remarkably high immunoreactive insulin levels. His phenotypic and laboratory features were consistent with a diagnosis of leprechaunism. We observed some effect of treatment with metformin but not with insulin glargine.
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Authors | Mehmet Emre Atabek, Ozgur Pirgon |
Journal | Journal of pediatric endocrinology & metabolism : JPEM
(J Pediatr Endocrinol Metab)
Vol. 19
Issue 10
Pg. 1257-61
(Oct 2006)
ISSN: 0334-018X [Print] Germany |
PMID | 17172088
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Hypoglycemic Agents
- Insulin
- Insulin, Long-Acting
- Insulin Glargine
- Metformin
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Topics |
- Abnormalities, Multiple
(drug therapy, metabolism)
- Fatal Outcome
- Humans
- Hyperglycemia
(drug therapy, metabolism)
- Hypoglycemic Agents
(therapeutic use)
- Infant, Newborn
- Insulin
(analogs & derivatives, therapeutic use)
- Insulin Glargine
- Insulin Resistance
(physiology)
- Insulin, Long-Acting
- Male
- Metformin
(therapeutic use)
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