Abstract | BACKGROUND: Most of the commonly used markers of chronic alcohol abuse reflect alcohol hepatotoxicity; however, such abuse is deleterious to the kidneys as well. Combined use of serum markers of liver origin and urinary markers of kidney origin may be of diagnostic advantage. METHODS: RESULTS: The discriminative power of the urinary markers matched that of the serum markers. Hex and GGT appeared to be the best for discriminating the study groups. Their combination given by the equation G&H=0.62 x ln(GGT)+0.72 x ln(Hex) showed excellent discriminative ability (ROC area under the curve 0.92) that was significantly higher than that of any single marker in this report, indicating superior diagnostic accuracy of the compound marker. CONCLUSIONS: Kidney-derived urinary markers, particularly Hex, can complement or replace, if necessary, serum markers of chronic alcohol abuse that relate to alcohol hepatotoxicity. The compound marker proposed seems a promising tool for the monitoring and perhaps detection of chronic alcohol abuse and warrants further studies.
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Authors | Ewa Taracha, Bogusław Habrat, Stanisław J Chrapusta, Małgorzata Lehner, Aleksandra Wisłowska, Bohdan T Woronowicz, Marta Bogulas, Jolanta Charewicz, Cezary Markuszewski, Adam Płaźnik |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 44
Issue 12
Pg. 1446-52
( 2006)
ISSN: 1434-6621 [Print] Germany |
PMID | 17163821
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- gamma-Glutamyltransferase
- Aspartate Aminotransferases
- Alanine Transaminase
- beta-N-Acetylhexosaminidases
- CD13 Antigens
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Topics |
- Adult
- Aged
- Alanine Transaminase
(blood)
- Alcoholism
(complications, diagnosis)
- Aspartate Aminotransferases
(blood)
- Biomarkers
(analysis, blood, urine)
- CD13 Antigens
(urine)
- Discriminant Analysis
- Factor Analysis, Statistical
- Humans
- Kidney Diseases
(diagnosis, etiology, physiopathology)
- Kidney Function Tests
- Linear Models
- Liver Diseases
(diagnosis, etiology, physiopathology)
- Liver Function Tests
- Male
- Middle Aged
- ROC Curve
- beta-N-Acetylhexosaminidases
(urine)
- gamma-Glutamyltransferase
(blood)
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