[Lipid reducing and antioxidant action of mexicor in patients with diabetes mellitus type 2].

Abstract

AIM:

To study mexicor effects on functional activity of beta-cells, insulin resistance, lipid metabolism and lipid peroxidation in patients with diabetes mellitus (DM) type 2.

MATERIAL AND METHODS:

Twenty patients with DM type 2 participated in a double blind randomized trial of mexicor vs placebo. Before and after therapy the following parameters were studied: plasma glucose before meal, immunoreactive insulin, glycosilated hemoglobin, cholesterol, triglycerides, LDLP and HDLP cholesterol, malonic dialdehyde, dienic conjugates, superoxide dismutase, catalase, glutathione peroxidase and alpha-tocopherol.

RESULTS:

Mexicor significantly improved compensation of carbohydrate metabolism by glucose and glycosylated hemoglobin in the blood, insulin resistance value, lipid metabolism and lipid peroxidation in activation of antioxidant enzymes.

CONCLUSION:

Mexicor in therapy of DM type 2 improves carbohydrate and lipid metabolism, lipid peroxidation, activates antioxidant defence enzymes, functional activity of beta-cells, reduces insulin resistance.

• Authors: E M Klebanova, M I Balabolkin, V M Kreminskaia, L D Smirnov
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 78 Issue 8 Pg. 67-70 ( 2006) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 17078221 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Antioxidants
• Blood Glucose
• Insulin
• Lipids
• Picolines
• emoxypine succinate

Topics

• Antioxidants (therapeutic use)
• Blood Glucose (metabolism)
• Diabetes Mellitus, Type 2 (blood, drug therapy)
• Double-Blind Method
• Follow-Up Studies
• Humans
• Insulin (blood)
• Lipid Peroxidation (drug effects)
• Lipids (blood)
• Picolines (therapeutic use)
• Treatment Outcome